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merck millipore,默克密理博,MAB10139,Anti-LIM Domain Only 2 Antibody, clone 2E6
产品名称：Anti-LIM Domain Only 2 Antibody, clone 2E6
产品型号：MAB10139
Detect LIM Domain Only 2 using this Anti-LIM Domain Only 2 Antibody, clone 2E6 validated for use in WB.
merck millipore,默克密理博,MAB10139,Anti-LIM Domain Only 2 Antibody, clone 2E6
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB M Culture Supernatant Monoclonal Antibody 描述 产品目录编号 MAB10139 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-LIM Domain Only 2 Antibody, clone 2E6 背景信息 LIM Domain only 2 (LMO2) encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. 产品信息 格式 Culture Supernatant 演示 Liquid containing 0.1% sodium azide. 应用 应用 Detect LIM Domain Only 2 using this Anti-LIM Domain Only 2 Antibody, clone 2E6 validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Recombinant human LMO2 克隆 2E6 宿主 Mouse 特异性 Human 同种型 IgG2a 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_005574.2
Entrez基因汇总 LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. 基因符号 - RBTNL1
- LMO2
- RHOM2
- TTG2
- RBTN2
- Rhombotin-2
UniProt编号 - P25791
UniProt汇总 FUNCTION: SwissProt: P25791 # Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
SIZE: 158 amino acids; 18358 Da
SUBUNIT: Interacts via its LIM domains with ELF2 and LBD1. Also interacts with basic helix-loop-helix protein TAL1/SCL and can assemble in a complex with LMO2 and TAL1/SCL (By similarity). Interacts with BEX2 and JARID1A.
SUBCELLULAR LOCATION: Nucleus (Potential).
DOMAIN: SwissProt: P25791 The second LIM zinc-binding domain interacts with JARID1A.
DISEASE:SwissProt: P25791 # A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD.
SIMILARITY: Contains 2 LIM zinc-binding domains.产品使用声明 质量保证 Routinely evaluated by immunoblot. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 1 year at 4°C from date of shipment 包装信息 数量 100 µL
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