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merck millipore,默克密理博,MABF70,Anti-TLR6 Antibody, clone 11C5.1
产品名称：Anti-TLR6 Antibody, clone 11C5.1
产品型号：MABF70
This Anti-TLR6 Antibody, clone 11C5.1 is validated for use in Western Blotting, Flow Cytometry, IHC for the detection of TLR6.
merck millipore,默克密理博,MABF70,Anti-TLR6 Antibody, clone 11C5.1
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB, FC M Purified Monoclonal Antibody 描述 产品目录编号 MABF70 描述 Anti-TLR6 Antibody, clone 11C5.1 Alternate Names - CD286
- Toll-like receptor 6
背景信息 Toll-like receptor 6 (TLR6) is a transmembrane protein that has been detected on plasmacytoid pre-dendritic cells, dermal microvessel endothelial cells, and CD11c+ dendritic cells. As a member of the toll-like receptor family, it contains multiple leucine rich repeats in the extracellular domain and a IL1 receptor motif in the cytoplasmic domain. TLR6 is a pattern-recognition receptor that recognizes pathogen-associated molecular patterns (PAMPs) on microbial agents. It recognizes mycoplasmal macrophage-activating lipopeptide (MALP-2); soluble tuberculosis factor (STF); phenol-soluble modulin (PSM); and B. burgdorferi outer surface protein A lipoprotein (OspA-L). TLR6 interacts with the MYD88 adaptor protein to activate NF-kappa B signaling pathway leading to the secretion of cytokines and the induction of inflammatory responses. 产品信息 格式 Purified 控制 - Raji cell lysate
演示 Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide. 应用 应用 This Anti-TLR6 Antibody, clone 11C5.1 is validated for use in Western Blotting, Flow Cytometry, IHC for the detection of TLR6. 主要应用 - Immunohistochemistry
- Western Blotting
- Flow Cytometry
应用说明 Flow Cytometry Analysis: 1 µg from a representative lot detected TLR6 in 1X10E6 human PBMCs.
Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected TLR6 in human tonsil tissue. A 1:1,000 dilution may be required to remove background staining.生物信息 免疫原品种 Linear peptide corresponding to human TLR6 at the LRR 8 repeat region. 表位 LRR 8 repeat region 克隆 11C5.1 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody recognizes TLR6 at the LRR 8 repeat region. 同种型 IgMκ 品种反应性 Human Species Reactivity Note Demonstrated to react with human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_006059
Entrez基因汇总 The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations. 基因符号 - TLR6
纯化方法 Purified by ion-exchange chromatography UniProt编号 - Q9Y2C9
UniProt汇总 FUNCTION: Participates in the innate immune response to Gram-positive bacteria and fungi. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2.
SUBUNIT STRUCTURE: Binds TLR2 via their respective extracellular domains. Binds MYD88 via their respective TIR domains.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle > phagosome membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.产品使用声明 质量保证 Evaluated by Western Blot in Raji cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected TLR6 in 10 µg of Raji cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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下一件merck millipore产品：merck millipore,默克密理博,ABT301,Anti-TPM2 Antibody
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