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经验配方 CAS号 C₄₇H₆₈O₁₇ 83314-01-6 描述 概述 A macrocyclic lactone with antitumor properties. Potently activates protein kinase C and exhibits a high binding affinity (Ki = 1.35 nM). Effectively translocates and down-regulates PKC isozymes α, δ, and ε. Induces a biphasic activation of PKD through a PKC-dependent pathway in intact cells. Also shown to activate Ras in Jurkat T cells and in rat2 cells. 产品目录编号 203811 品牌系列 Calbiochem®
同义词 Bryo 1, PKC Activator VII, PKC Activator VI 参考 参考 Clamp, A., and Jayson, G. 2002. Anticancer Drugs 13, 673.
Lorenzo, P.S., et al. 1999. Cancer Res. 59, 6137.
Wang, Q.J., et al. 1999. J. Biol. Chem. 274, 37233.
Wender, P.A., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 6624.
Matthews, S.A., et al. 1997. J. Biol. Chem. 272, 20245.
Szallasi, Z., et al. 1994. Mol. Pharmacol. 46, 840.
Berkow, R.L., and Kratt, A.S. 1985. Biochem. Biophys. Res. Commun. 3, 1109.产品信息 CAS号 83314-01-6 具有ATP竞争性 N 形式 Colorless solid or film Hill配方 C₄₇H₆₈O₁₇ 化学配方 C₄₇H₆₈O₁₇ Molar Mass 905.1 可逆 N 结构配方图像 生物信息 主靶 Protein kinase C 主靶Ki 1.35 nM for protein kinase C 纯度 ≥98% by TLC 理化信息 细胞可渗透 N 溶解度 DMSO or EtOH GHS安全信息 RTECS EH9455000 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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