merck millipore,默克密理博,MABF512,Anti-CD11b Antibody (human/mouse), APC-Cy7, clone M1/70

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
M, H	FC, IHC	R	APC-Cy7	Monoclonal Antibody

描述
产品目录编号	MABF512
描述	Anti-CD11b Antibody (human/mouse), APC-Cy7, clone M1/70
Alternate Names	CD antigen CD11b Integrin alpha-M CD11 antigen-like family member B CR-3 alpha chain Cell surface glycoprotein MAC-1 subunit alpha Leukocyte adhesion receptor MO1 Neutrophil adherence receptor
背景信息	The M1/70 antibody reacts with human and mouse CD11b, also known as integrin alpha M. This 165-170 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha M (CD11b) assembles with Integrin beta-2 (CD18) into a receptor known as Macrophage Antigen-1 (Mac-1) or complement receptor type 3 (CR3). This receptor binds and induces intracellular signaling through ICAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.The M1/70 antibody is widely used as a marker for CD11b expression on mouse macrophages, granulocytes, neutrophils, and NK cells. The antibody is also reported to be cross-reactive for Rhesus macaque CD11b.

产品信息
格式	APC-Cy7
演示	Purified Rat Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.

应用
应用	This rat monoclonal antibody Anti-CD11b (human/mouse), APC-Cy7, clone M1/70 validated for use in IP, IHC, Flow Cytometry & Immunofluorescence for the detection of CD11b.
主要应用	Flow Cytometry Immunohistochemistry

生物信息
免疫原品种	Immunogen information for this antibody is proprietary information.
克隆	M1/70
浓缩	0.2 mg/mL
宿主	Rat
同种型	IgG2bκ
品种反应性	MouseHuman
抗体类型	Monoclonal Antibody
基因符号	CR3A ITGAM CD11B
纯化方法	Size Exclusion Chromatography
UniProt编号	P11215 P05555

产品使用声明
质量保证	The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation. Flow Cytometry Analysis: 0.125 μg of this antibody detected CD11b in one million C57Bl/6 bone marrow cells.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

包装信息
数量	25 µg

merck millipore,默克密理博,MABF512,Anti-CD11b Antibody (human/mouse), APC-Cy7, clone M1/70

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