merck millipore,默克密理愽
  • merck millipore,默克密理博,MABF41,Anti-Interleukin-6 (IL-6) Antibody, clone 1G3

  • merck millipore,默克密理博,MABF41,Anti-Interleukin-6 (IL-6) Antibody, clone 1G3

    产品名称：Anti-Interleukin-6 (IL-6) Antibody, clone 1G3
    产品型号：MABF41
    Anti-Interleukin-6 (IL-6) Antibody, clone 1G3 is an antibody against Interleukin-6 (IL-6) for use in WB.

    merck millipore,默克密理博,MABF41,Anti-Interleukin-6 (IL-6) Antibody, clone 1G3

  • 产品介绍
  • merck millipore,默克密理博,MABF41,Anti-Interleukin-6 (IL-6) Antibody, clone 1G3

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABF41
    Replaces 04-1095
    描述 Anti-Interleukin-6 (IL-6) Antibody, clone 1G3
    Alternate Names
    • interleukin BSF-2
    • interleukin 6 (interferon, beta 2)
    • IFN-beta-2
    • B-cell stimulatory factor 2
    • interleukin-6
    • Interferon beta-2
    • B cell stimulatory factor-2
    • Hybridoma growth factor
    • B-cell differentiation factor
    • CTL differentiation factor
    背景信息 Interleukin-6 (IL-6) is a pro-inflammatory cytokine that seems to be involved in the late stages of CTL generation. Other biological functions also include amplification and the inflammatory response. Combination therapies including IL-6 have been shown to have positive effects on specific malignant tumor types. The accumulation of IL-6 in the CNS is usually detrimental and can contribute to pathology of CNS diseases. IL-6 signaling is negatively regulated by TGF-beta, which down regulates STAT1, STAT3 and ICAM-1 expression. IL-6 expression has been linked to inflammatory bowel disease (IBD) and is also the primary clinical target for IBD. Clinical use of an antibody for the IL-6 receptor (IL-6R) has been promising in treating rheumatoid arthritis, systemic juvenile idiopathic arthritis and Castleman’s disease.
    产品信息
    格式 Purified
    控制
    • Human IL-6 recombinant protein
    演示 Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-Interleukin-6 (IL-6) Antibody, clone 1G3 is an antibody against Interleukin-6 (IL-6) for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Human IL-6 fused to the soluble domain of the IL-6R.
    克隆 AB42_51.38C8.1G3
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG2bκ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_000591
    Entrez基因汇总 This gene encodes a cytokine that functions in inflammation and the maturation of B cells. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq].
    基因符号
    • BSF-2
    • IL6
    • IL-6
    • CDF
    • HSF
    • HGF
    • BSF2
    • IFNB2
    纯化方法 Protein G Purified
    UniProt编号
    • P05231
    UniProt汇总 FUNCTION: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.

    SUBCELLULAR LOCATION: Secreted.

    PTM: N- and O-glycosylated.

    POLYMORPHISM: Genetic variations in IL6 may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.

    INVOLVEMENT IN DISEASE: Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.

    Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.

    SEQUENCE SIMILARITIES: Belongs to the IL-6 superfamily.
    产品使用声明
    质量保证 Evaluated by Western Blot in lysate from cells expressing human IL-6 recombinant protein.

    Western Blot Analysis: 0.5 µg/mL of this antibody detected 10 µg of human IL-6 recombinant protein.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABF41,Anti-Interleukin-6 (IL-6) Antibody, clone 1G3

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