merck millipore,默克密理愽
  • merck millipore,默克密理博,MABF268,Anti-IRF3 Antibody, clone SL-12

  • merck millipore,默克密理博,MABF268,Anti-IRF3 Antibody, clone SL-12

    产品名称：Anti-IRF3 Antibody, clone SL-12
    产品型号：MABF268
    This Anti-IRF3 Antibody, clone SL-12 is validated for use in Western Blotting and Immunocytochemistry and Immunoprecipitation for the detection of IRF3.

    merck millipore,默克密理博,MABF268,Anti-IRF3 Antibody, clone SL-12

  • 产品介绍
  • merck millipore,默克密理博,MABF268,Anti-IRF3 Antibody, clone SL-12

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HICC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABF268
    Replaces MABF21
    描述 Anti-IRF3 Antibody, clone SL-12
    Alternate Names
    • IRF-3
    • Interferon regulatory factor 3
    背景信息 Interferon regulatory factors (IRFs) comprise a family of transcription factors that function with the Jak/Stat pathway to regulate interferon (IFN) and IFN-inducible gene expression in response to viral infection. IRF-3 can inhibit cell growth and plays a critical role in controlling the expression of genes in the innate immune response. In unstimulated cells, IRF-3 is present in the cytoplasm. Viral infection results in phosphorylation of IRF-3 and leads to its translocation to the nucleus where it activates promoters containing IRF-3-binding sites. Phosphorylation of IRF-3 occurs at a cluster of C-terminal serine and threonine residues (between 385 and 405) leading to its association with the p300/CBP coactivator protein that promotes DNA binding and transcriptional activity.
    产品信息
    格式 Purified
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Anti-IRF3 Antibody, clone SL-12 is validated for use in Western Blotting and Immunocytochemistry and Immunoprecipitation for the detection of IRF3.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry Analysis: A 1:50 dilution from a representative lot detected IRF3 in HeLa, A-431, HepG2, and NIH/3T3 cells. DyLight 488® is a registered trademark of Thermo Fisher Scientific.
    Immunoprecipitation Analysis: A representative lot immunoprecipitated IRF3 in HEC1B cells treated or untreated with virus and M059J DNA-PK - and M059J cells with DNA-PK+ (Karpova, A.Y., et al. (2002). PNAS. 99(5):2818-2823).
    Western Blotting Analysis: A representative lot detected IRF3 in HFK (human foreskin keratinocytes) cells expressing BPV ORF's (Ronco, L.V., et al. (1998) Genes Dev. 12:2061-2072).
    Western Blotting Analysis: A representative lot detected IRF3 in Transfected Mock and SeV infected 293 cells (Basler, C.F., et al. (2003) Journal of Virology. 77(14):7945-7956).
    Immunocytochemistry Analysis: A representative lot detected IRF3 in hec-1b cells infected with delNS1 or PR8 (Talon. J., et al. (2000). Journal of Virology. 74(17):7989-7996).
    Immunocytochemistry Analysis: A representative lot detected IRF3 in HEC1B cells treated or untreated with virus (Karpova, A.Y., et al. (2002). PNAS. 99(5):2818-2823).
    生物信息
    免疫原品种 Recombinant protein corresponding to human IRF3.
    克隆 SL-12
    浓缩 Please refer to lot specific datasheet.
    宿主 Mouse
    同种型 IgG1κ
    品种反应性 MouseHuman
    Species Reactivity Note Human, Mouse.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001184051
    基因符号
    • IRF3
    纯化方法 Protein G purified
    UniProt编号
    • Q14653
    产品使用声明
    质量保证 Evaluated by Western Blotting in HeLa cell lysate.

    Western Blotting Analysis: 1.0 µg/mL of this antibody detected IRF3 in 10 µg of HeLa cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABF268,Anti-IRF3 Antibody, clone SL-12

上一件merck millipore产品：merck millipore,默克密理博,SLHA033SB,Millex-HA 过滤器，0.45 µm，混合纤维素酯，33 mm，环氧乙烷灭菌
下一件merck millipore产品：merck millipore,默克密理博,208735,Calmodulin Inhibitory Peptide - Calbiochem


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