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merck millipore,默克密理博,MAB2627,Anti-VCAM-1 (CD106) Antibody, clone 6C7.1
产品名称：Anti-VCAM-1 (CD106) Antibody, clone 6C7.1
产品型号：MAB2627
Anti-VCAM-1 (CD106) Antibody, clone 6C7.1 is an antibody against VCAM-1 (CD106) for use in FC, IP, IC, IH.
merck millipore,默克密理博,MAB2627,Anti-VCAM-1 (CD106) Antibody, clone 6C7.1
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M IHC, FC, ICC R Purified Monoclonal Antibody 描述 产品目录编号 MAB2627 描述 Anti-VCAM-1 (CD106) Antibody, clone 6C7.1 Alternate Names - CD106 antigen
- vascular cell adhesion molecule 1
- vascular cell adhesion protein 1
背景信息 Vascular cell adhesion protein 1 (VCAM-1) is a cell surface adhesion molecule belonging to the immunoglobulin cell-cell adhesion receptor family and is comprised of seven Ig-like C2-type domains. VCAM-1 is a crucial component in cell-cell recognition and seems to be involved in cellular adhesion between endothelial cells and leukocytes. It has a regulatory role for both signal transduction and adhesion through its interaction with leukocyte beta-1 integrin VLA4, an interaction that is potentially involved in immune and inflammatory emigration responses of leukocytes. Studies have shown upregulation of VCAM-1 to be critical in responding to inflammatory diseases such as atherosclerosis. VCAM-1 is primarily expressed in endothelial cells and is expressed as two known isoforms found within the cell membrane. Isoform 1 functions as a single-pass type 1 membrane protein, while Isoform 2 acts as a GPI-anchor. 产品信息 格式 Purified 控制 - Mouse bone marrow cells
演示 Purified rat monoclonal IgG1κ in buffer containing PBS without preservative. 应用 应用 Anti-VCAM-1 (CD106) Antibody, clone 6C7.1 is an antibody against VCAM-1 (CD106) for use in FC, IP, IC, IH. 主要应用 - Immunohistochemistry
- Flow Cytometry
- Immunocytochemistry
应用说明 Immunohistochemistry Analysis: A previous lot was used by independent laboratory in IH. (Norman, U., et al. (2008). Journal of Leukocyte Biology. 84:68-76.)
Immunocytochemistry Analysis: A previous lot was used by independent laboratory in IC. (Norman, U., et al. (2008). Journal of Leukocyte Biology. 84:68-76.)生物信息 免疫原品种 Mouse endothelial cells 克隆 6C7.1 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rat 同种型 IgG1κ 品种反应性 Mouse Species Reactivity Note Demonstrated to react with mouse. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_035823
基因符号 - L1CAM
- VCAM1
- VCAM-1
- CD106
- V-CAM 1
- INCAM-100
纯化方法 Protein G UniProt编号 - P29533
UniProt汇总 FUNCTION: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
SUBUNIT STRUCTURE: Binds to ECMV-D capsid proteins and acts as a receptor for this virus.
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cell membrane; Lipid-anchor › GPI-anchor.
TISSUE SPECIFICTY: Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Expressed in the bone marrow.
PTM: The GPI-anchor is located on position 319 of isoform 2.
SEQUENCE SIMILARITIES: Contains 7 Ig-like C2-type (immunoglobulin-like) domains.产品使用声明 质量保证 Evaluated by Flow Cytometry in mouse bone marrow cells.
Flow Cytometry Analysis: 10 µg of this antibody detected VCAM-1 on mouse bone marrow cells.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µg
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