merck millipore,默克密理愽
  • merck millipore,默克密理博,MABE270,Anti-phospho STAT6 (Tyr641) Antibody, clone 19E2.1

  • merck millipore,默克密理博,MABE270,Anti-phospho STAT6 (Tyr641) Antibody, clone 19E2.1

    产品名称：Anti-phospho STAT6 (Tyr641) Antibody, clone 19E2.1
    产品型号：MABE270
    Anti-phospho STAT6 (Tyr641) Antibody, clone 19E2.1 is a mouse monoclonal antibody for detection of phospho STAT6 (Tyr641) also known as Signal transducer & activator of transcription 6, IL-4 Stat & ha More>>

    merck millipore,默克密理博,MABE270,Anti-phospho STAT6 (Tyr641) Antibody, clone 19E2.1

  • 产品介绍
  • merck millipore,默克密理博,MABE270,Anti-phospho STAT6 (Tyr641) Antibody, clone 19E2.1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HFC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABE270
    描述 Anti-phospho STAT6 (Tyr641) Antibody, clone 19E2.1
    Alternate Names
    • IL-4 Stat
    • Signal transducer and activator of transcription 6
    背景信息 Signal transducer and activator of transcription 6 (STAT6) transduces signals from extracellular cytokines during adaptive immunity and has recently been found to be important in the innate immune response to viral infection. STAT6 is also involved in the attenuation of the Th1 and Th17 in the nephritogenic immune response. The consequence of STAT6 activity has been associated with the pathogenesis of autoimmune disease and has been found to be actively imported to the nucleus.
    产品信息
    格式 Purified
    控制
    • NIH/3T3 cell lysates treated and untreated with PDGF
    演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-phospho STAT6 (Tyr641) Antibody, clone 19E2.1 is a mouse monoclonal antibody for detection of phospho STAT6 (Tyr641) also known as Signal transducer & activator of transcription 6, IL-4 Stat & has been validated in WB, FC.
    主要应用
    • Flow Cytometry
    • Western Blotting
    应用说明 Flow Cytometry Analysis: 2 µg/mL from a representative lot detected STAT6 in human peripheral blood leukocytes.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human STAT6 phosphorylated at (Tyr641).
    表位 Phosphorylated (Tyr641)
    克隆 19E2.1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes STAT6 phosphorylated at (Tyr641).
    同种型 IgG2aκ
    品种反应性 MouseHuman
    Species Reactivity Note Demonstrated to react with Human and Mouse.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001171549
    Entrez基因汇总 The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
    基因符号
    • STAT6
    修改
    • Phosphorylation
    纯化方法 Protein G purified
    UniProt编号
    • P42226
    UniProt汇总 FUNCTION: Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.

    SUBUNIT STRUCTURE: Forms a homodimer or a heterodimer with a related family member By similarity. Interacts with NCOA1 via its C-terminal LXXLL motif.

    SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note: Translocated into the nucleus in response to phosphorylation.

    PTM: Tyrosine phosphorylated following stimulation by IL-4 and IL-3 (By similarity).

    SEQUENCE SIMILARITIES: Belongs to the transcription factor STAT family.

    Contains 1 SH2 domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in NIH/3T3 cell lysates treated and untreated with PDGF.

    Western Blot Analysis: 0.5 µg/mL of this antibody detected STAT6 on 10 µg of PDGF untreated and treated NIH/3T3 cell lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABE270,Anti-phospho STAT6 (Tyr641) Antibody, clone 19E2.1

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