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merck millipore,默克密理博,361558,GSK-3 Inhibitor XV - Calbiochem
产品名称：GSK-3 Inhibitor XV - Calbiochem
产品型号：361558
The GSK-3 Inhibitor XV controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
merck millipore,默克密理博,361558,GSK-3 Inhibitor XV - Calbiochem
- 产品介绍
重要规格表
经验配方 C₂₅H₁₄BrN₃O₆Ru 描述 概述 The racemic mixture of a cell-permeable pyridocarbazolo-cyclopentadienyl Ruthenium complex that acts as a reversible, ATP-competitive, and highly potent inhibitor of GSK-3 (IC50 = 0.4 and 0.6 nM for GSK-3α and GSK-3β, respectively) with ∼5-fold selectivity over PIM-1 kinase (IC50 = 3 nM). Studies using isolated enantiomers have shown that the (R)-enantiomer is GSK-3-selective (IC50 = 0.35, 0.55, and 35 nM for GSK-3α GSK-3β, and Pim-1, respectively) and interferes with normal zebrafish embryo development (1 µM), while the (S)-enantiomer is Pim-1-selective (IC50 = 80, 90, and 3 nM for GSK-3α GSK-3β, and Pim-1, respectively) and exhibits no effect in embryo development at the same dosage. 产品目录编号 361558 品牌系列 Calbiochem®
参考 参考 Atilla-Gokcumen, G.E., et al. 2006. ChemBioChem 7, 1443. 产品信息 具有ATP竞争性 Y 声明 Sold for research purposes only, pursuant to an agreement with University of Pennsylvania. Sold under license of U.S. Patent 7,488,817. 形式 Purple solid Hill配方 C₂₅H₁₄BrN₃O₆Ru 化学配方 C₂₅H₁₄BrN₃O₆Ru Molar Mass 633.4 可逆 Y 结构配方图像 生物信息 主靶 GSK-3 主靶IC50 0.4 and 0.6 nM for GSK-3α and GSK-3β, respectively 纯度 ≥98% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Blue Ice Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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