merck millipore,默克密理博,MABC742,Anti-phospho-IRE1 (Ser724), clone EPR5253, Rabbit Monoclonal Antibody

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merck millipore,默克密理博,MABC742,Anti-phospho-IRE1 (Ser724), clone EPR5253, Rabbit Monoclonal Antibody
产品名称：Anti-phospho-IRE1 (Ser724), clone EPR5253, Rabbit Monoclonal Antibody
产品型号：MABC742
This Anti-phospho-IRE1 (Ser724), clone EPR5253, Rabbit Monoclonal Antibody is validated for use in Western Blotting and Flow Cytometry for the detection of phospho-IRE1 (Ser724).

merck millipore,默克密理博,MABC742,Anti-phospho-IRE1 (Ser724), clone EPR5253, Rabbit Monoclonal Antibody

产品介绍

merck millipore,默克密理博,MABC742,Anti-phospho-IRE1 (Ser724), clone EPR5253, Rabbit Monoclonal Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	FC, WB	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	MABC742
描述	Anti-phospho-IRE1 (Ser724), clone EPR5253, Rabbit Monoclonal Antibody
Alternate Names	IRE1a Serine/threonine-protein kinase/endoribonuclease IRE1 Endoplasmic reticulum-to-nucleus signaling 1 Inositol-requiring protein 1 hIRE1p Ire1-alpha
背景信息	Inositol-requiring protein 1 (IRE1p), also known as Ire1-alpha (IRE1a), Endoplasmic reticulum-to-nucleus signaling 1 (ERN1), and Serine/threonine-protein kinase/endoribonuclease IRE1, contains 1 KEN domain and 1 protein kinase domain. IRE1p has an endoribonuclease activity that is required to splice X-box binding protein (XBP1) mRNA converting it to a potent UPR transcriptional activation. Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER. IRE1p is ubiquitously expressed with high levels observed in pancreatic tissue.

产品信息
格式	Unpurified
演示	Rabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.

应用
应用	This Anti-phospho-IRE1 (Ser724), clone EPR5253, Rabbit Monoclonal Antibody is validated for use in Western Blotting and Flow Cytometry for the detection of phospho-IRE1 (Ser724).
主要应用	Flow Cytometry Western Blotting
应用说明	Flow Cytometry Analysis: A 1:1,000 dilution from a representative lot detected phospho-IRE1 (Ser724) in Raji cells. Produced in collaboration with Epitomics™

生物信息
免疫原品种	Synthetic peptide corresponding to human phospho-IRE1 (Ser724).
克隆	EPR5253
浓缩	Please refer to lot specific datasheet.
宿主	Rabbit
同种型	IgG
品种反应性	Human
Species Reactivity Note	Human
抗体类型	Monoclonal Antibody
基因符号	IRE1 ERN1
纯化方法	Unpurified
UniProt编号	O75460

产品使用声明
质量保证	Evaluated by Western Blotting in Untreated HEK293 and Calyculin A treated with HEK293 cell lysates. Western Blotting Analysis: A 1:1,000-10,000 dilution of this antibody detected phospho-IRE1 (Ser724) in Untreated HEK293 and Calyculin A treated with HEK293 cell lysates.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.