merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB5592,Anti-Nerve Growth Factor Receptor Antibody, clone MLR2

  • merck millipore,默克密理博,MAB5592,Anti-Nerve Growth Factor Receptor Antibody, clone MLR2

    产品名称：Anti-Nerve Growth Factor Receptor Antibody, clone MLR2
    产品型号：MAB5592
    Anti-Nerve Growth Factor Receptor Antibody, clone MLR2 detects level of Nerve Growth Factor Receptor & has been published & validated for use in IH.

    merck millipore,默克密理博,MAB5592,Anti-Nerve Growth Factor Receptor Antibody, clone MLR2

  • 产品介绍
  • merck millipore,默克密理博,MAB5592,Anti-Nerve Growth Factor Receptor Antibody, clone MLR2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MIHCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB5592
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Nerve Growth Factor Receptor Antibody, clone MLR2
    产品信息
    格式 Purified
    控制
    • Brain tissue
    演示 Purified immunoglobulin. Lyophilized. Contains no preservative. Reconstitute with 100 μL of sterile distilled water.
    应用
    应用 Anti-Nerve Growth Factor Receptor Antibody, clone MLR2 detects level of Nerve Growth Factor Receptor & has been published & validated for use in IH.
    主要应用
    • Immunohistochemistry
    应用说明 Immunohistochemistry on motor neurons in spinal cord with lesioned siatic nerve:

    1-2 μg/mL. Suggested fixative is 4% formaldehyde. The antibody has not yet been tested on paraffin embedded tissue.

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Human p75 coupled to an Fc fragment.
    克隆 MLR2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Nerve Growth Factor Receptor (NGF Receptor p75).
    同种型 IgG2a
    品种反应性 RatHumanMouse
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_002507
    Entrez基因汇总 Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain.
    基因符号
    • TNFRSF16
    • NGFR
    • Gp80-LNGFR
    • CD271
    • p75(NTR)
    纯化方法 Protein A purfied
    UniProt编号
    • P08138
    UniProt汇总 FUNCTION: SwissProt: P08138 # Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
    SIZE: 427 amino acids; 45183 Da
    SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    DOMAIN: SwissProt: P08138 Death domain is responsible for interaction with RANBP9.
    PTM: N- and O-glycosylated. & O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc. & Phosphorylated on serine residues.
    SIMILARITY: Contains 1 death domain. & Contains 4 TNFR-Cys repeats.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C to -70°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (ASC grade or better) can be added (1:1) for additional stability.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB5592,Anti-Nerve Growth Factor Receptor Antibody, clone MLR2

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