merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB5268,Anti-Chromogranin A Antibody, clone LK2H10

  • merck millipore,默克密理博,MAB5268,Anti-Chromogranin A Antibody, clone LK2H10

    产品名称：Anti-Chromogranin A Antibody, clone LK2H10
    产品型号：MAB5268
    Detect Chromogranin A using this Anti-Chromogranin A Antibody, clone LK2H10 validated for use in IH, IH(P) & WB.

    merck millipore,默克密理博,MAB5268,Anti-Chromogranin A Antibody, clone LK2H10

  • 产品介绍
  • merck millipore,默克密理博,MAB5268,Anti-Chromogranin A Antibody, clone LK2H10

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, M, Mk, PoWB, IHCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB5268
    Replaces CBL219
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Chromogranin A Antibody, clone LK2H10
    Alternate Names
    • Pituitary Secretory Protein I
    • CgA
    背景信息 Chromogranin A (a protein of 439 amino acids which is encoded on chromosome 14) is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, phenochromocytomas, paragangliomas, and other neuroendocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.
    产品信息
    格式 Purified
    控制
    • Pancreas, adrenal gland, bowel and thyroid tissues Immunoblot: PC12 cell lysate, human pancreatic tissue
    演示 Purified mouse monoclonal IgG1 in buffer containing 0.05M Borate buffered saline, 0.15M NaCl, pH 8.2 with 0.1% sodium azide.
    应用
    应用 Detect Chromogranin A using this Anti-Chromogranin A Antibody, clone LK2H10 validated for use in IH, IH(P) & WB.
    主要应用
    • Western Blotting
    • Immunohistochemistry
    应用说明 Immunohistochemistry:
    A 1-10 μg/mL concentration of a previous lot was used in IH.

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Human pheochromocytoma
    克隆 LK2H10
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Chromogranin, an acidic protein having a molecular weight of about 68 kDa abides in the polypeptide-hormone-containing secretory granules of human endocrine tissues. Anti-chromogranin A can be used to stain most normal and neoplastic endocrine tissues containing secretory granules (exceptions include cells from the hypothalamus and posterior pituitary, which are known to contain secretory granules). The amount of staining is usually proportional to the number of secretory granules present (1).
    同种型 IgG1κ
    品种反应性 RatHumanMouseMonkeyPig
    Species Reactivity Note Human, mouse, rat, monkey, and porcine. Does not recognize sheep, rabbit or guinea pig.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001266
    Entrez基因汇总 The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown.
    基因符号
    • CGA
    • CHGA
    • CgA
    • SP-I
    纯化方法 Ammonium sulfate precipitation
    UniProt编号
    • P10645
    UniProt汇总 FUNCTION: SwissProt: P10645 # Pancreastatin strongly inhibits glucose induced insulin release from the pancreas.
    SIZE: 457 amino acids; 50730 Da
    SUBCELLULAR LOCATION: Secreted. Note=Neuroendocrine and endocrine secretory granules.
    PTM: Sulfated on tyrosine residues and/or contains sulfated glycans.
    SIMILARITY: SwissProt: P10645 ## Belongs to the chromogranin/secretogranin protein family.
    MISCELLANEOUS: Binds calcium with a low-affinity
    产品使用声明
    质量保证 Routinely evaluated by Western Blot on Mouse Pancreas lysates.

    Western Blot Analysis:
    1:1000 dilution of this lot detected Chromogranin A on 10 μg of Mouse Pancreas lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 6 months at 2-8ºC in undiluted aliquots from date of receipt.
    包装信息
    数量 500 µg
    包装 500 μL

    merck millipore,默克密理博,MAB5268,Anti-Chromogranin A Antibody, clone LK2H10

上一件merck millipore产品：merck millipore,默克密理博,ABE1034,Anti-Tet1 Antibody
下一件merck millipore产品：merck millipore,默克密理博,420175,Cancer Hydrolase KIAA1363 Inhibitor, JW480 - CAS 1354359-53-7 - Calbiochem


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