merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB5264,Anti-Nerve Growth Factor Receptor (p75) Antibody, clone 8211

  • merck millipore,默克密理博,MAB5264,Anti-Nerve Growth Factor Receptor (p75) Antibody, clone 8211

    产品名称：Anti-Nerve Growth Factor Receptor (p75) Antibody, clone 8211
    产品型号：MAB5264
    Anti-Nerve Growth Factor Receptor (p75) Antibody, clone 8211 is an antibody against Nerve Growth Factor Receptor (p75) for use in IC, IH, IH(P) & WB.

    merck millipore,默克密理博,MAB5264,Anti-Nerve Growth Factor Receptor (p75) Antibody, clone 8211

  • 产品介绍
  • merck millipore,默克密理博,MAB5264,Anti-Nerve Growth Factor Receptor (p75) Antibody, clone 8211

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWB, ICC, IHCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB5264
    Replaces 04-1111
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Nerve Growth Factor Receptor (p75) Antibody, clone 8211
    Alternate Names
    • NGFR
    • NGF-Receptor p75
    • Low Affinity NGF Receptor
    背景信息 The low affinity NGFR (Nerve growth factor receptor) is a 75kDa membrane-spanning glycoprotein lacking intrinsic tyrosine kinase activity. p75NGFR interacts with TrkA, the high affinity NGF receptor and potentiates TrkA signaling at low NGF concentrations. The p75 receptor binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NGFR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death. It is expressed on many neuronal cells types including many embryonic forms and the receptor can be used to isolate neuronal progenitor cells.
    产品信息
    格式 Purified
    控制
    • Brain tissue
    演示 Protein A Purified mouse immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative.
    应用
    应用 Anti-Nerve Growth Factor Receptor (p75) Antibody, clone 8211 is an antibody against Nerve Growth Factor Receptor (p75) for use in IC, IH, IH(P) & WB.
    主要应用
    • Western Blotting
    • Immunocytochemistry
    • Immunohistochemistry
    应用说明 Immunohistochemistry: 5-10 μg/mL

    Immunocytochemistry: 5-10 μg/mL

    Immunohistochemistry on paraffin sections: Cattoretti, Blood 81:1726-1738, 1993.

    Western Blot: 1ug/mL

    Immunoabsorptive purification of NGF-receptors

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Membrane fragments of the melanoma cell line WM-9 (Herlyn et al., 1983).
    克隆 8211
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Reacts with NGF-receptors in human system.
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_002507.2
    Entrez基因汇总 Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain.
    基因符号
    • NT-3
    • NTF3
    • NT3
    • NGF2
    • HDNF
    • MGC129711
    • NGF-2
    纯化方法 Protein A purfied
    UniProt编号
    • P08138
    UniProt汇总 FUNCTION: SwissProt: P08138 # Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
    SIZE: 427 amino acids; 45183 Da
    SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    DOMAIN: SwissProt: P08138 Death domain is responsible for interaction with RANBP9.
    PTM: N- and O-glycosylated. & O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc. & Phosphorylated on serine residues.
    SIMILARITY: Contains 1 death domain. & Contains 4 TNFR-Cys repeats.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,MAB5264,Anti-Nerve Growth Factor Receptor (p75) Antibody, clone 8211

上一件merck millipore产品：merck millipore,默克密理博,ABC88,Anti-FK506-binding protein-like (FKBPL) Antibody
下一件merck millipore产品：merck millipore,默克密理博,70751,BugBuster Ni-NTA His•Bind Purification Kit


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