merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB5258-50UG,Anti-Synaptophysin Antibody, clone SY38

  • merck millipore,默克密理博,MAB5258-50UG,Anti-Synaptophysin Antibody, clone SY38

    产品名称：Anti-Synaptophysin Antibody, clone SY38
    产品型号：MAB5258-50UG
    Anti-Synaptophysin Antibody, clone SY38 detects level of Synaptophysin & has been published & validated for use in WB, IC, IH.

    merck millipore,默克密理博,MAB5258-50UG,Anti-Synaptophysin Antibody, clone SY38

  • 产品介绍
  • merck millipore,默克密理博,MAB5258-50UG,Anti-Synaptophysin Antibody, clone SY38

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    F, H, M, R, B, AvIHC, WB, ICCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB5258-50UG
    Replaces 04-1019
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Synaptophysin Antibody, clone SY38
    Alternate Names
    • Major synaptic vesicle protein p38
    背景信息 Synaptophysin is a synaptic vesicle glycoprotein with four transmembrane domains weighing 38 kDa. It is present in neuroendocrine cells and in virtually all neurons in the brain and spinal cord that participate in synaptic transmission. The localization and ubiquitous expression of this protein in neuronal tissue makes it an excellent marker for neurons and neuroendocrine tumors. The gene for this protein is located on the X chromosome (Xp11.23-p11.22). The exact function of the protein is unknown: it interacts with the essential synaptic vesicle protein synaptobrevin, but when the synaptophysin gene is experimentally inactivated in animals, they still develop and function normally.
    产品信息
    格式 Purified
    控制
    • Positive Control: Pancreas
      Negative Control: Normal mouse serum
    演示 Purified mouse monoclonal IgG1κ liquid in buffer containing 20 mM sodium phosphate buffer, 5 mg/mL BSA, with 0.01% methylisothiazolone MIT (w/v), pH 7.5.
    应用
    应用 Anti-Synaptophysin Antibody, clone SY38 detects level of Synaptophysin & has been published & validated for use in WB, IC, IH.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    • Immunocytochemistry
    应用说明 Immunohistochemistry: For relatively cytoplasm rich neuroendocrinic tumors a final concentration of 1 μg/mL is recommended. A final concentration of 2 μg/mL is recommended for cytoplasm deficient tumors.
    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Vesicular fraction of bovine brain
    克隆 clone SY38)
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 The antibody reacts with presynaptic vesicles of cerebral and spinal neurons, of neuromuscular endplates and with the retina of man, cow, rat and mouse. The antibody also reacts with vesicles of adrenal medulla and islet cells, and additionally allows specific staining of neuronal, adrenal and neuroepithelial tumors, such as pheochromocytoma, paraganglioma, islet cell tumors (incl. Insulinoma), medullary thyroid carcinoma and diverse pulmonary and gastro-intestinal carcinoids. The antibody also stains neurosecretory vesicles of certain culture cells, e.g. of the rat cell line PC-12.
    同种型 IgG1κ
    品种反应性 FishHumanMouseRatBovineAvian
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_003179.2
    Entrez基因汇总 Synaptophysin (p38) is an integral membrane protein of small synaptic vesicles in brain and endocrine cells.[supplied by OMIM]
    基因符号
    • Synaptophysin
    • SYP
    • synaptophysin
    纯化方法 Protein A purfied
    UniProt编号
    • P08247
    UniProt汇总 FUNCTION: SwissProt: P08247 # Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane.
    SIZE: 313 amino acids; 33845 Da
    SUBUNIT: Homohexamer or homotetramer.
    SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein.
    TISSUE SPECIFICITY: Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.
    DOMAIN: SwissProt: P08247 The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.
    PTM: Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation (By similarity).
    SIMILARITY: Belongs to the synaptophysin/synaptobrevin family. & Contains 1 MARVEL domain.
    产品使用声明
    质量保证 Evaluated by Western Blot on mouse brain lysates.

    Western Blot Analysis: 1:1000 dilution of this antibody detected synaptophysin on 10 ug of mouse brain lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at from date of receipt.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,MAB5258-50UG,Anti-Synaptophysin Antibody, clone SY38

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