merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB5256B,Anti-Neurofilament 200kDa Antibody, clone NE14, Biotin Conjugate

  • merck millipore,默克密理博,MAB5256B,Anti-Neurofilament 200kDa Antibody, clone NE14, Biotin Conjugate

    产品名称：Anti-Neurofilament 200kDa Antibody, clone NE14, Biotin Conjugate
    产品型号：MAB5256B
    Anti-Neurofilament 200kDa Antibody, clone NE14, Biotin Conjugate detects level of Neurofilament 200kDa & has been published & validated for use in ICC & IHC.

    merck millipore,默克密理博,MAB5256B,Anti-Neurofilament 200kDa Antibody, clone NE14, Biotin Conjugate

  • 产品介绍
  • merck millipore,默克密理博,MAB5256B,Anti-Neurofilament 200kDa Antibody, clone NE14, Biotin Conjugate

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Po, M, R, HIHC, ICCMBiotinMonoclonal Antibody
    描述
    产品目录编号 MAB5256B
    描述 Anti-Neurofilament 200kDa Antibody, clone NE14, Biotin Conjugate
    Alternate Names
    • Neurofilament triplet H protein
    • Neurofilament heavy polypeptide
    • NF-H
    • 200 kDa neurofilament protein
    背景信息 Neurofilaments are a type of intermediate filament that serve as major elements of the cytoskeleton supporting the axon cytoplasm. They are the most abundant fibrillar components of the axon, being on average 3-10 times more frequent than axonal microtubules. Neurofilaments (10nm in dia.) are built from three intertwined protofibrils which are themselves composed of two tetrameric protofilament complexs of monomeric proteins. The neurofilament triplet proteins (68/70, 160, and 200 kDa) occur in both the central and peripheral nervous system and are usually neuron specific. The 68/70 kDa NF-L protein can self-assemble into a filamentous structure, however the 160 kDa NF-M and 200 kDa NF-H proteins require the presence of the 68/70 kDa NF-L protein to co-assemble. Neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas and neuroblastomas stain positively for neurofilaments. Although typically restricted to neurons, neurofilaments have been detected in paragangliomas and adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and oat cell carcinomas of the lung also express neurofilaments. For more neurofilament information and epitope maps, search "neurofilament" on our website.
    产品信息
    格式 Biotin
    控制
    • Rat E18 primary cortex cells
    演示 Purified mouse monoclonal IgG1 conjugated to Biotin in PBS with 0.1% sodium azide and 15 mg/mL BSA.
    应用
    应用 Anti-Neurofilament 200kDa Antibody, clone NE14, Biotin Conjugate detects level of Neurofilament 200kDa & has been published & validated for use in ICC & IHC.
    主要应用
    • Immunohistochemistry
    • Immunocytochemistry
    应用说明 Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected Neurofilament in adult mouse brain cryosections.
    生物信息
    免疫原品种 Purified human neurofilament polypeptides (Debus et al., 1983).
    克隆 NE14
    宿主 Mouse
    同种型 IgG1
    品种反应性 PigMouseRatHuman
    Species Reactivity Note Demonstrated to react with Mouse, and Rat. Predicted to react with Human and Porcine based on 100% sequence homology.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_066554
    Entrez基因汇总 Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq, Oct 2008].
    基因符号
    • NFH
    • NEFH
    纯化方法 Protein A purified
    UniProt编号
    • P12036
    UniProt汇总 FUNCTION: Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins.

    SIZE: 1026 amino acids; 112480 Da

    PTM: There are a number of repeats of the tripeptide K-S-P, NFH is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFH results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber. & Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincident with a change in the neurofilament function.

    DISEASE: Defects in NEFH are a cause of susceptibility to amyotrophic lateral sclerosis (ALS) [MIM:105400]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors.

    SIMILARITY: Belongs to the intermediate filament family.
    产品使用声明
    质量保证 Evaluated by Immunocytochemistry in rat E18 primary cortex cells.

    Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Neurofilament in rat E18 primary cortex cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MAB5256B,Anti-Neurofilament 200kDa Antibody, clone NE14, Biotin Conjugate

上一件merck millipore产品：merck millipore,默克密理博,AB2295,Anti-phospho GluR4 (Ser842) Antibody
下一件merck millipore产品：merck millipore,默克密理博,575307,T113242 - CAS 195533-44-9 - Calbiochem


相关产品

merck millipore,默克密理博,AB19016,Anti-MMP-9 Antibody, Catalytic domain merck millipore,默克密理博,AB19016,Anti-MMP-9 Antibody, Catalytic domain

merck millipore,默克密理博,AB10557,Anti-Lhx2 Antibody merck millipore,默克密理博,AB10557,Anti-Lhx2 Antibody

merck millipore,默克密理博,AB4125,Anti-FOXA2 Antibody merck millipore,默克密理博,AB4125,Anti-FOXA2 Antibody

merck millipore,默克密理博,CC1022,Human Integrin αVβ5, Octyl-β-D-glucopyranoside Formulation merck millipore,默克密理博,CC1022,Human Integrin αVβ5, Octyl-β-D-glucopyranoside Formulation

merck millipore,默克密理博,AB2295,Anti-phospho GluR4 (Ser842) Antibody merck millipore,默克密理博,AB2295,Anti-phospho GluR4 (Ser842) Antibody

merck millipore,默克密理博,575307,T113242 - CAS 195533-44-9 - Calbiochem merck millipore,默克密理博,575307,T113242 - CAS 195533-44-9 - Calbiochem

merck millipore,默克密理博,540222,Puromycin, Dihydrochloride - CAS 58-58-2 - Calbiochem merck millipore,默克密理博,540222,Puromycin, Dihydrochloride - CAS 58-58-2 - Calbiochem

merck millipore,默克密理博,MABE193,Anti-YBOX1/YB-1 Antibody, clone EP2706Y, rabbit monoclonal merck millipore,默克密理博,MABE193,Anti-YBOX1/YB-1 Antibody, clone EP2706Y, rabbit monoclonal

merck millipore,默克密理博,MABF313,Anti-CD3 (mouse) Antibody, PE, clone 17A2 merck millipore,默克密理博,MABF313,Anti-CD3 (mouse) Antibody, PE, clone 17A2

merck millipore,默克密理博,252805,DHEA - CAS 53-43-0 - Calbiochem merck millipore,默克密理博,252805,DHEA - CAS 53-43-0 - Calbiochem


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部