merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB5254,Anti-Neurofilament 160 kDa Antibody, clone NN18

  • merck millipore,默克密理博,MAB5254,Anti-Neurofilament 160 kDa Antibody, clone NN18

    产品名称：Anti-Neurofilament 160 kDa Antibody, clone NN18
    产品型号：MAB5254
    Anti-Neurofilament 160 kDa Antibody, clone NN18 is an antibody against Neurofilament 160 kDa for use in IH, IH(P) & WB.

    merck millipore,默克密理博,MAB5254,Anti-Neurofilament 160 kDa Antibody, clone NN18

  • 产品介绍
  • merck millipore,默克密理博,MAB5254,Anti-Neurofilament 160 kDa Antibody, clone NN18

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    H, Ch, Gp, M, Po, RWB, IHCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB5254
    Replaces CBL214
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Neurofilament 160 kDa Antibody, clone NN18
    背景信息 Neurofilaments are a type of intermediate filament that serve as major elements of the cytoskeleton supporting the axon cytoplasm. They are the most abundant fibrillar components of the axon, being on average 3-10 times more frequent than axonal microtubules. Neurofilaments (10nm in dia.) are built from three intertwined protofibrils which are themselves composed of two tetrameric protofilament complexs of monomeric proteins. The neurofilament triplet proteins (68/70, 160, and 200 kDa) occur in both the central and peripheral nervous system and are usually neuron specific. The 68/70 kDa NF-L protein can self-assemble into a filamentous structure, however the 160 kDa NF-M and 200 kDa NF-H proteins require the presence of the 68/70 kDa NF-L protein to co-assemble. Neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas and neuroblastomas stain positively for neurofilaments. Although typically restricted to neurons, neurofilaments have been detected in paragangliomas and adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and oat cell carcinomas of the lung also express neurofilaments. For more neurofilament information see Nervous System Cell Type Specific Marker chart online under the CHEMICON Technical Support section.
    产品信息
    格式 Purified
    控制
    • Cultured neurons
    • Brain
    演示 Purified mouse monoclonal IgG1 in buffer containing 0.02M Phosphate buffer, 0.25M NaCl with 0.1% sodium azide.
    应用
    应用 Anti-Neurofilament 160 kDa Antibody, clone NN18 is an antibody against Neurofilament 160 kDa for use in IH, IH(P) & WB.
    主要应用
    • Western Blotting
    • Immunohistochemistry
    应用说明 Immunohistochemistry:
    5-10 µg/mL on frozen or paraffin embedded tissue. See protocols for details.

    Western Blot:
    1:1000. 7.5%-10% SDS-PAGE

    Optimal working dilutions and protocols must be determined by end user.
    生物信息
    免疫原品种 Purified neurofilament polypeptides.
    克隆 NN18
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 The antibody reacts with neurofilament 160 kD (Debus, E., 1982; Shaw, G., 1984).
    同种型 IgG1
    品种反应性 HumanChickenGuinea PigMousePigRat
    Species Reactivity Note Expected to react with human based on sequence homology.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_001105541.1
    基因符号
    • NFM
    • NEFM
    • NF-M
    • NEF3
    纯化方法 Protein A purfied
    UniProt编号
    • P07197
    UniProt汇总 FUNCTION: SwissProt: P07197 # Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.
    SIZE: 916 amino acids; 102448 Da
    PTM: There are a number of repeats of the tripeptide K-S-P, NFM is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFM results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber. & Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincident with a change in the neurofilament function.
    SIMILARITY: SwissProt: P07197 ## Belongs to the intermediate filament family.
    产品使用声明
    质量保证 Routinely evaluated by Western Blot on PC12 lysates.

    Western Blot Analysis:
    1:500 dilution of this lot detected Neurofilament on 10 μg of PC12 lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 6 months at 2-8ºC in undiluted aliquots from date of receipt.
    Do not freeze.
    包装信息
    数量 40 µg

    merck millipore,默克密理博,MAB5254,Anti-Neurofilament 160 kDa Antibody, clone NN18

上一件merck millipore产品：merck millipore,默克密理博,344289,Freund’s Complete Adjuvant, Modified, Mycobacterium butyricum
下一件merck millipore产品：merck millipore,默克密理博,SCR012,PluriStem 129/S6 Murine ES cells


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