merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB4429,Anti-BMP-7 (Pro-peptide) Antibody, clone 2

  • merck millipore,默克密理博,MAB4429,Anti-BMP-7 (Pro-peptide) Antibody, clone 2

    产品名称：Anti-BMP-7 (Pro-peptide) Antibody, clone 2
    产品型号：MAB4429
    Anti-BMP-7 (Pro-peptide) Antibody, clone 2 is an antibody against BMP-7 (Pro-peptide) for use in WB, IH(P), ELISA & IC.

    merck millipore,默克密理博,MAB4429,Anti-BMP-7 (Pro-peptide) Antibody, clone 2

  • 产品介绍
  • merck millipore,默克密理博,MAB4429,Anti-BMP-7 (Pro-peptide) Antibody, clone 2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HICC, WB, ELISAMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB4429
    描述 Anti-BMP-7 (Pro-peptide) Antibody, clone 2
    Alternate Names
    • Eptotermin alfa
    • bone morphogenetic protein 7
    • Osteogenic protein 1
    背景信息 Bone morphogenetic protein-7 (BMP-7), also known as osteogenic protein-1, is a member of the TGF- superfamily, and is widely expressed during embryonic development. Like other members of the bone morphogenetic protein family, BMP-7 works synergistically with BMP-2 to play a key role in the differentiation of mesenchymal cells into bone and cartilage tissues by actively recruiting stem cells from the surrounding tissue, thereby initiating the bone formation cascade. In adult cells, BMP-7 is predominately expressed in the brain, kidneys, and bladder.
    产品信息
    格式 Purified
    控制
    • Human kidney tissue lysate
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
    应用
    应用 Anti-BMP-7 (Pro-peptide) Antibody, clone 2 is an antibody against BMP-7 (Pro-peptide) for use in WB, IH(P), ELISA & IC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    • ELISA
    应用说明 ELISA Analysis: A previous lot was used by an independent laboratory in ELISA (Gregory, K.E., et al., 2005).

    Immunocytochemistry Analysis: A previous lot was used by an independent laboratory in IC (Gregory, K.E., et al., 2005).

    Immunohistochemistry (paraffin) Analysis: A 1:200 dilution of a previous lot was used to detect BMP-7 (pro-peptide) in human kidney tissue.
    A previous lot was used by an independent laboratory in IH (Gregory, K.E., et al., 2005).
    生物信息
    免疫原品种 Recombinant protein corresponding to human BMP-7 (Pro-peptide).
    表位 Unknown
    克隆 mab 2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes the pro-peptide form of BMP-7.
    同种型 IgG1κ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001710
    Entrez基因汇总 The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. [provided by RefSeq].
    基因符号
    • OP-1
    • BMP7
    • BMP-7
    • OP1
    纯化方法 Protein G purfied
    UniProt编号
    • P18075
    UniProt汇总 FUNCTION: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.

    SUBUNIT STRUCTURE: Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1 By similarity.

    SUBCELLULAR LOCATION: Secreted.

    TISSUE SPECIFICITY: Expressed in the kidneys and bladder. Lower levels seen in the brain.

    PTM: Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms (Ref.5).

    PHARMACEUTICAL USE: Available under the names Osigraft (Stryker). Its use is indicated in the treatment of tibial non-union of at least 9 month duration, secondary to trauma, in skeletally mature patients, in cases where autograft has failed or is unfeasible.

    SEQUENCE SIMILARITIES: Belongs to the TGF-beta family.
    产品使用声明
    质量保证 Evaluated by Western Blot in human kidney tissue lysate.

    Western Blot Analysis: 0.5 µg/mL of this antibody detected BMP-7 (Pro-peptide) in 10 µg of human kidney tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB4429,Anti-BMP-7 (Pro-peptide) Antibody, clone 2

上一件merck millipore产品：merck millipore,默克密理博,14-742M,FGFR2 (N549H) Protein, active, 250 µg
下一件merck millipore产品：merck millipore,默克密理博,PEZGS0416,Millicell EZ SLIDE 4-well glass, sterile


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