merck millipore,默克密理博,MAB4369,Anti-SRF [Serum Response Factor] Antibody, clone 1E1

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
M, H	ICC, WB	M	Purified	Monoclonal Antibody

描述
产品目录编号	MAB4369
描述	Anti-SRF [Serum Response Factor] Antibody, clone 1E1
Alternate Names	serum response factor (c-fos serum response element-binding transcription factor)
背景信息	Serum response factor (SRF) is a nuclear transcription factor that binds to the serum response element (SRE), and is essential for embryonic development of the mesoderm, as well as for the maintenance of adult muscle cells and neurons. As this protein is involved in the downstream regulation of many immediate-early genes, it participates in a variety of cell functions, including cell cycle, apoptosis, cell growth, and cell differentiation. SRF is most commonly activated by serum, LPA, LPS, TPA, growth factors, including TNFalpha, as well as antioxidants and UV light.

产品信息
格式	Purified
演示	Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl, and 0.05% sodium azide.

应用
应用	Detect SRF [Serum Response Factor] using this Anti-SRF [Serum Response Factor] Antibody, clone 1E1 validated for use in WB & IC.
主要应用	Immunocytochemistry Western Blotting
应用说明	Immunocytochemistry: Recommended working dilution is 1:500.

生物信息
免疫原品种	Synthetic human SRF peptide, a.a. 406-508.
克隆	1E1
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
特异性	This monoclonal antibody recognizes SRF.
同种型	IgG1κ
品种反应性	MouseHuman
Species Reactivity Note	Reacts with human. A weak interaction with mouse has also been observed. Reactivity with other species has not been tested.
抗体类型	Monoclonal Antibody
Entrez基因编号	P11831
基因符号	SAP2 ELK3 ERP MCM1 OTTHUMP00000039820
纯化方法	Protein G purfied
UniProt编号	P11831
UniProt汇总	FUNCTION: SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentation and maturation. SUBUNIT STRUCTURE: Binds DNA as a multimer, probably a dimer. Interacts with MLLT7/FOXO4, NKX3A and SSRP1. Interacts with ARID2 and SRFBP1 By similarity. Forms complexes with ARID2, MYOCD, NKX2-5 and SRFBP1 By similarity. SUBCELLULAR LOCATION: Nucleus. PTM: Phosphorylated by PRKDC. SEQUENCE SIMILARITIES: Contains 1 MADS-box domain.

产品使用声明
质量保证	(Based upon representative data from a previous lot). Western Blotting: Recommended working dilution is 0.5 µg/mL.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. Avoid repeat freeze/thaw cycles.

包装信息
数量	100 µg

merck millipore,默克密理博,MAB4369,Anti-SRF [Serum Response Factor] Antibody, clone 1E1

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