merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB425,Anti-Carcinoembryonic Antigen Antibody, clone 1105

  • merck millipore,默克密理博,MAB425,Anti-Carcinoembryonic Antigen Antibody, clone 1105

    产品名称：Anti-Carcinoembryonic Antigen Antibody, clone 1105
    产品型号：MAB425
    Detect Carcinoembryonic Antigen using this Anti-Carcinoembryonic Antigen Antibody, clone 1105 validated for use in ELISA, RIA.

    merck millipore,默克密理博,MAB425,Anti-Carcinoembryonic Antigen Antibody, clone 1105

  • 产品介绍
  • merck millipore,默克密理博,MAB425,Anti-Carcinoembryonic Antigen Antibody, clone 1105

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HELISAMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB425
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Carcinoembryonic Antigen Antibody, clone 1105
    Alternate Names
    • CD66e
    • CEACAM5
    • Carcinoembryonic antigen-related cell adhesion molecule 5
    • Carcinoembryonic antigen
    • CEA
    • Meconium antigen 100
    背景信息 The carcinoembryonic antigen- (CEA-) related cell adhesion molecules (CEACAMs) constitute a 12-member subgroup of the CEA family of immunoglobulin-related proteins first described in 1965 (PMID 4953873). CEACAMs are reported to participate in diverse physiological processes, including cell adhesion, differentiation, proliferation, and survival, as well as in carcinogenesis and bacterial pathogenesis. CEACAM molecules from neighbouring cells can interact via their respective extracellular N-terminal IgV-like domain and mediate cell-cell adhesion through trans-oligomerization. CEACAM molecules within the same cell can also undergo transmembrane domain-mediated cis-oligomerization, an event important for sustaining downstream cellular signaling. Athough CEACAM1 is shown to utilize its cytoplasmic domain for transducing cellular signaling, not all CEACAM members are expressed with a significant cytoplasmic domain, and others (CEACAM5/6/7/8) are GPI-anchored without even a transmembrane domain. (PMID 4735478). Human CEACAM5 (also known as CD66e, CEA, Ceacam5, Meconium antigen 100; UniProt P06731) is encoded by the CEACAM5 (or CEA) gene (NCBI Gene ID 1048). It is a GPI-anchored CEACAM with the most extracellular Ig domains, 7 in all.
    产品信息
    格式 Purified
    演示 Purified immunoglobulin (Protein A). Liquid in PBS, pH 7.4 containing 0.1% sodium azide.
    应用
    应用 Detect Carcinoembryonic Antigen using this Anti-Carcinoembryonic Antigen Antibody, clone 1105 validated for use in ELISA, RIA.
    主要应用
    • ELISA
    应用说明 Sandwich RIA or EIA

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Purified CEA from pooled tumors.
    克隆 1105
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Human Carcinoembryonic Antigen (CEA)
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001278413
    基因符号
    • CEA
    • CEACAM5
    UniProt编号
    • P06731
    UniProt汇总 SIZE: 526 amino acids; 57560 Da
    SUBCELLULAR LOCATION: Isoform A: Cell membrane; Single-pass type I membrane protein. & Isoform B: Cell membrane; Single-pass type I membrane protein. & Isoform C: Cell membrane; Single-pass type I membrane protein. & Isoform G: Secreted. & Isoform H: Secreted. & Isoform I: Secreted.
    DISEASE:SwissProt: P13688 # Loss or reduced expression is a major event in colorectal carcinogenesis. & Increased serum levels of BGP-1 are found in individuals suffering from hepatic disorders.
    SIMILARITY: SwissProt: P13688 ## Belongs to the immunoglobulin superfamily. CEA family. & Contains 3 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store below -20°C or in dry ice as precipitation will occur.
    包装信息
    数量 500 µg

    merck millipore,默克密理博,MAB425,Anti-Carcinoembryonic Antigen Antibody, clone 1105

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下一件merck millipore产品：merck millipore,默克密理博,0500-2260,Guava Flow Cell (HT Systems)


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