merck millipore,默克密理博,MAB4081,Anti-MnSOD Antibody, clone MnS-1

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
Rb, H, R	IHC, WB, ICC	M	Purified	Monoclonal Antibody

描述
产品目录编号	MAB4081
品牌系列	Chemicon®
商名	Chemicon
描述	Anti-MnSOD Antibody, clone MnS-1
Alternate Names	MnSOD

产品信息
格式	Purified
演示	Purified immunoglobulin. Liquid in PBS.

应用
应用	This Anti-MnSOD Antibody, clone MnS-1 is validated for use in WB, IC, IH for the detection of MnSOD.
主要应用	Immunohistochemistry Western Blotting Immunocytochemistry
应用说明	Immunohistochemistry on acetone fixed cryostat sections: 0.5-10 μg/mL using an APAAP or PAP procedure. Antibody also reacts with 4% PFA fixed frozen tissue. Typical block contains 1% non-fat dry milk or 3% NGS and 0.2-1.5% triton X-100 {higher triton is only used on thick sections; blocked for 1-3 hours at room temperature. Primary antibody is diluted only in PBS or TBS without excess blocking materials (no triton or milk); typical dilution is 1:200-1:1000 with incubations up to 48 hours at 4C. Washed 3x10' in PBS and detect via DAB. Immunoreactive neurons are characterized by the dark brown, fine granular deposition in soma and proximal dendrites. Immunocytochemistry on cell smears: 0.5-10 μg/mL. Western blot: MnS1 antibody will recognize at 25kDa band under reducing conditions; this is the monomer of the MnSOD protein. Optimal working dilutions must be determined by end user.

生物信息
克隆	MnS-1
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
特异性	Antibody reacts with MnSOD
同种型	IgG1
品种反应性	RabbitHumanRat
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_001024466.1 NM_000636.2 NM_001024465.1
Entrez基因汇总	This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
基因符号	EC 1.15.1.1 SOD2 MNSOD MnSOD IPO-B Mn-SOD
非反应性品种	Mouse
UniProt编号	P04179
UniProt汇总	FUNCTION: SwissProt: P04179 # Destroys radicals which are normally produced within the cells and which are toxic to biological systems. COFACTOR: Binds 1 manganese ion per subunit. SIZE: 222 amino acids; 24722 Da SUBUNIT: Homotetramer. SUBCELLULAR LOCATION: Mitochondrion matrix.SIMILARITY:SwissProt: P04179 ## Belongs to the iron/manganese superoxide dismutase family.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Prior to opening maintain at 2-8°C for up to six month after date of receipt. After opening maintain at -20°C in undiluted aliquots for up to six months. Avoid repeated freeze/thaw cycles.

包装信息
数量	100 µg

merck millipore,默克密理博,MAB4081,Anti-MnSOD Antibody, clone MnS-1

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