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主要应用 品种 来源 CULT Human Recombinant mature human PDGF-A chain and PDGF-B chain expressed in E. coli and dimerized in vitro. 描述 产品目录编号 01-310 品牌系列 Upstate
商名 - Upstate
描述 PDGF-AB Protein, human 产品信息 演示 Lypholized from of 10mM acetic acid 应用 应用 The human PDGF-AB Protein is available in a 10 µg format. 主要应用 - Cell Culture
生物信息 来源 Recombinant mature human PDGF-A chain and PDGF-B chain expressed in E. coli and dimerized in vitro. 品种 Human Entrez基因编号 - NM_033023.3
- NM_002607.4
Entrez基因汇总 The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene. 基因符号 - PDGF1
- PDGFA
- PDGF-1
- PDGF-A
物理形式 Frozen liquid 纯化方法 Sterilized through a 0.2 micron membrane filter UniProt编号 - P01127
- P04085
UniProt汇总 FUNCTION: SwissProt: P04085 # Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.
SIZE: 211 amino acids; 24043 Da
SUBUNIT: Antiparallel disulfide-linked dimer of non-identical (A and B) chains. Homodimers of A and B chains are implicated in transformation processes. Interacts with CSPG4.
SUBCELLULAR LOCATION: Secreted.
DOMAIN: SwissProt: P04085 The long form contains a basic insert which acts as a cell retention signal.SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
MISCELLANEOUS: A-A and B-B, as well as A-B, dimers can bind to the PDGF receptor.产品使用声明 质量保证 Routinely evaluated in cell growth of NIH 3T3 fibroblasts over control cultures without PDGF-AB 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
包装信息 数量 10 µg
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