merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB3738,Anti-PML Antibody, clone 36.1-104

  • merck millipore,默克密理博,MAB3738,Anti-PML Antibody, clone 36.1-104

    产品名称：Anti-PML Antibody, clone 36.1-104
    产品型号：MAB3738
    Anti-PML Antibody, clone 36.1-104 is a Mouse Monoclonal Antibody for detection of PML also known as Promyelocytic Leukemia Protein & has been validated in ICC, IP & WB.

    merck millipore,默克密理博,MAB3738,Anti-PML Antibody, clone 36.1-104

  • 产品介绍
  • merck millipore,默克密理博,MAB3738,Anti-PML Antibody, clone 36.1-104

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    MWB, ICCMAscitesMonoclonal Antibody
    描述
    产品目录编号 MAB3738
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-PML Antibody, clone 36.1-104
    Alternate Names
    • Tripartite Motif Protein 19
    • Promyelocytic Leukemia Protein
    背景信息 PML protein is a tripartite motif (TRIM)-containing nuclear protein that may function as, among other things, a transcription factor, a coactivator of nuclear receptors (Ruggerio, 2000), a regulator of apoptosis (Guo, 2000), a mediator of interferon-induced antiviral response (Regand and Chelbi-Aliz, 2001), and as a suppressor of growth and oncogenic transformation (Mu, 1997). PML is localized to the nucleoplasm and in distinct subnuclear structures referred to as Promyelocytic Leukemia Bodies (also known as Nuclear Domain 10). Localization of PML to Promyelocytic Leukemia Bodies requires modification of PML protein by the Small Ubiquitin Modifier (SUMO) and is required for proper formation and integrity of these subnuclear structures. At least 14 splice variants of PML ranging in molecular weight from 48-97 kDa (predicted) have been described in the literature. The functional significance of the various splice variants is not well understood. In patients with Acute Promyelocytic Leukemia, the PML gene is involved in at least two specific chromosomal translocations that result in the expression of chimeric proteins with the Retinoic Acid Receptor alpha (RARalpha DNA- and Hormone-binding domains; Pandolfi, 2001). All isoforms of PML, as well as the PML-RARalpha chimeric proteins expressed in Type A and Type B APL contain an identical N-terminus but vary in the C-terminal portion of the protein (Jenson, 2001).
    产品信息
    格式 Ascites
    控制
    • POSITIVE CONTROL: Mouse embryo fibroblasts (MEF1 cells).
    演示 Ascites fluid containing no preservatives.
    应用
    应用 Anti-PML Antibody, clone 36.1-104 is a Mouse Monoclonal Antibody for detection of PML also known as Promyelocytic Leukemia Protein & has been validated in ICC, IP & WB.
    主要应用
    • Western Blotting
    • Immunocytochemistry
    应用说明 Western blot (1:500)

    Immunoprecipitation

    Immunocytochemistry (1:100)

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 His-tagged PML fusion protein corresponding to amino acids 1-581 of mouse PML.
    克隆 36.1-104
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Recognizes mouse PML (Promyelocytic Leukemia protein). On western blots of protein extracts from mouse embryo fibroblast (MEF1 cells), MAB3738 recognizes a band migrating at approximately 106 kDa corresponding to PML.
    同种型 IgG2b
    品种反应性 Mouse
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_033250.2
    • NM_002675.3
    • NM_033238.2
    • NM_033239.2
    • NM_033240.2
    • NM_033244.3
    • NM_033246.2
    • NM_033247.2
    • NM_033249.2
    Entrez基因汇总 The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.
    基因符号
    • MYL
    • PML
    • PP8675
    • RNF71
    • TRIM19
    非反应性品种
    • Human
    纯化方法 Unpurified
    UniProt编号
    • P29590
    UniProt汇总 FUNCTION: SwissProt: P29590 # Probable transcription factor. May play an important role in recruitment of ELF4 into PML nuclear bodies.
    SIZE: 882 amino acids; 97517 Da
    SUBUNIT: Interacts with SIRT1, TOPBP1, TRIM27 and TRIM69. Interacts with the C-terminus of ELF4. Interacts with Lassa virus Z protein and rabies virus phosphoprotein (By similarity).
    SUBCELLULAR LOCATION: Nucleus. Note=Localized to PML nuclear bodies.
    PTM: Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
    DISEASE: SwissProt: P29590 # A chromosomal aberration involving PML may be a cause of acute promyelocytic leukemia (APL). Translocation t(15;17)(q21;q21) with RARA. The PML breakpoints (type A and type B) lie on either side of an alternatively spliced exon.
    SIMILARITY: SwissProt: P29590 ## Contains 2 B box-type zinc fingers. & Contains 1 RING-type zinc finger.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MAB3738,Anti-PML Antibody, clone 36.1-104

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