merck millipore,默克密理博,555553,Rho Kinase Inhibitor III, Rockout - CAS 7272-84-6

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Merck Millipore 默克密理愽

merck millipore,默克密理博,555553,Rho Kinase Inhibitor III, Rockout - CAS 7272-84-6 - Calbiochem

经验配方	CAS号
C₁₃H₁₀N₂	7272-84-6

描述
概述	A cell-permeable indolopyridine compound that acts as a selective, reversible, and ATP-competitive inhibitor of Rho kinase activity with an IC₅₀ of 25 µM. Does not inhibit the activation of Rho kinase nor does it affect the in vitro activities of MLCK, PKCα, and SAPK2a/p38α. Shown to be 5-fold less potent than Y-27632 (Cat. No. 688000; IC₅₀ = ~5 µM), and display a similar specificity profile as H-89 (Cat. No. 371963). Affects cell migration, inhibits blebbing (IC₅₀ = ~ 12 µM in M2 cells), and decreases stress fibers in Bulb 3T3 cells at 50 µM.
产品目录编号	555553
品牌系列	Calbiochem®
同义词	3-(4-Pyridyl)-1H-indole

参考
参考	Yarrow, J.C., et al. 2005. Chem. Biol. 12, 385.

理化信息
细胞可渗透	Y
溶解度	DMSO or MeOH

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,555553,Rho Kinase Inhibitor III, Rockout - CAS 7272-84-6 - Calbiochem

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