merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB3680,Anti-Cyclin A Antibody, clone E23.1

  • merck millipore,默克密理博,MAB3680,Anti-Cyclin A Antibody, clone E23.1

    产品名称：Anti-Cyclin A Antibody, clone E23.1
    产品型号：MAB3680
    Detect Cyclin A with Anti-Cyclin A Antibody, clone E23.1 (Mouse Monoclonal Antibody), that has been shown to work in WB, ICC.

    merck millipore,默克密理博,MAB3680,Anti-Cyclin A Antibody, clone E23.1

  • 产品介绍
  • merck millipore,默克密理博,MAB3680,Anti-Cyclin A Antibody, clone E23.1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, B, HICC, WBMAscitesMonoclonal Antibody
    描述
    产品目录编号 MAB3680
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Cyclin A Antibody, clone E23.1
    产品信息
    格式 Ascites
    演示 Ascites fluid. Liquid. Contains no preservative.
    应用
    应用 Detect Cyclin A with Anti-Cyclin A Antibody, clone E23.1 (Mouse Monoclonal Antibody), that has been shown to work in WB, ICC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Western blot

    Immunocytochemistry

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Bovine Cyclin A fusion protein.
    克隆 E23.1
    宿主 Mouse
    特异性 Cyclin A. Cyclin A protein is absent in cells prior to S-phase, during which its levels increase and peak. MAB3680 is extremely sensitive for immunoblotting of Cyclin A. Cyclin A is involved in the regulation of the cell cycle and is essential for progression through S phase. Cyclin A is a marker for actively proliferating cells and for cells in S phase.
    同种型 IgG2a
    品种反应性 MouseBovineHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_003914.3
    • NM_001111045.1
    • NM_001111046.1
    • NM_001111047.1
    Entrez基因汇总 The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene.
    基因符号
    • Cyclin-A1.
    • CCNA1
    UniProt编号
    • P78396
    UniProt汇总 FUNCTION: SwissProt: P78396 # May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.
    SIZE: 465 amino acids; 52358 Da
    SUBUNIT: Interacts with the CDK2 and the CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Does not bind CDK4 and CDK5 (in vitro). The cyclin A1-CDK2 complex interacts with transcription factor E2F-1 and RB proteins. Found in a complex with CDK2, CABLES1 and CCNE1 (By similarity). Interacts with KLHDC9.
    TISSUE SPECIFICITY: Very high levels in testis and very low levels in brain. Also found in myeloid Leukemia cell lines.
    DEVELOPMENTAL STAGE: Expression increases in early G1 phase and reaches highest levels during the S and G2/M phases.
    SIMILARITY: SwissProt: P78396 ## Belongs to the cyclin family. Cyclin AB subfamily.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MAB3680,Anti-Cyclin A Antibody, clone E23.1

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