merck millipore,默克密理博,215921,Chlorpromazine, Hydrochloride - CAS 69-09-0

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merck millipore,默克密理博,215921,Chlorpromazine, Hydrochloride - CAS 69-09-0 - Calbiochem
产品名称：Chlorpromazine, Hydrochloride - CAS 69-09-0 - Calbiochem
产品型号：215921
Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC₅₀ = 17 µM).

merck millipore,默克密理博,215921,Chlorpromazine, Hydrochloride - CAS 69-09-0 - Calbiochem

产品介绍

merck millipore,默克密理博,215921,Chlorpromazine, Hydrochloride - CAS 69-09-0 - Calbiochem

重要规格表

经验配方	CAS号
C₁₇H₁₉ClN₂S · HCl	69-09-0

描述
概述	Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC₅₀ = 17 µM). Acts as a peripheral vasodilator. Acts as an inhibitor of lysosomal sphingomyelinase and of TNF-α production. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in murine lung. Shown to potently and specifically inhibit KSP/Eg5 (IC₅₀ < 10 µM), and PLA2.
产品目录编号	215921
品牌系列	Calbiochem®
同义词	2-Chloro-10-[3ʹ-(dimethylamino)propyl]phenothiazine, HCl

参考
参考	Lee, M.S., et al. 2007. Cancer Res. 67, 11359. Maor, I., et al. 1995. Arteriosclero. Thromb. Vasc. Biol. 15, 1378. Netea, M.G., et al. 1995. J. Infect. Dis. 171, 393. Lindahl, M., and Tagesson, C. 1993. Inflammation 17, 573. Palacios, M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 280. Yamamoto, H. 1993. Toxicol. Lett. 66, 73. Vadas, P., et al. 1986. Agents Actions 19, 194. Marshak, P.R., et al. 1985. Biochemistry 24, 144.

参考

Lee, M.S., et al. 2007. Cancer Res. 67, 11359.
Maor, I., et al. 1995. Arteriosclero. Thromb. Vasc. Biol. 15, 1378.
Netea, M.G., et al. 1995. J. Infect. Dis. 171, 393.
Lindahl, M., and Tagesson, C. 1993. Inflammation 17, 573.
Palacios, M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 280.
Yamamoto, H. 1993. Toxicol. Lett. 66, 73.
Vadas, P., et al. 1986. Agents Actions 19, 194.
Marshak, P.R., et al. 1985. Biochemistry 24, 144.

产品信息
CAS号	69-09-0
具有ATP竞争性	N
形式	Off-white crystalline solid
Hill配方	C₁₇H₁₉ClN₂S · HCl
化学配方	C₁₇H₁₉ClN₂S · HCl
Molar Mass	355.3
吸湿	Hygroscopic
可逆	N
结构配方图像

生物信息
主靶	Calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase
主靶IC₅₀	17 µM inhibiting calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase
纯度	≥99% by titration

理化信息
细胞可渗透	N
污染物	Heavy metals: ≤0.002%; iron: ≤0.001%; sulfate: ≤0.05%
溶解度	MeOH or H₂O

GHS安全信息
RTECS	SO1750000

安全信息
R相	R: 25-26-36/37/38 Toxic if swallowed. Very toxic by inhalation. Irritating to eyes, respiratory system and skin.
S相	S: 22-26-36/37/39-45 Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Toxic
有害材料注意事项：	Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存	+15°C to +30°C
吸湿	Hygroscopic
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C and for up to 1 week at 4°C.