merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB3414,Anti-Cytokeratin 8 Antibody, clone 4.1.18

  • merck millipore,默克密理博,MAB3414,Anti-Cytokeratin 8 Antibody, clone 4.1.18

    产品名称：Anti-Cytokeratin 8 Antibody, clone 4.1.18
    产品型号：MAB3414
    This Anti-Cytokeratin 8 Antibody, clone 4.1.18 is validated for use in WB, IC, IH, IH(P) for the detection of Cytokeratin 8.

    merck millipore,默克密理博,MAB3414,Anti-Cytokeratin 8 Antibody, clone 4.1.18

  • 产品介绍
  • merck millipore,默克密理博,MAB3414,Anti-Cytokeratin 8 Antibody, clone 4.1.18

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHC, WB, ICCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB3414
    Replaces 04-588
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Cytokeratin 8 Antibody, clone 4.1.18
    产品信息
    格式 Purified
    演示 Lyophilized from 0.02 M Phosphate buffer, 0.25 M NaCl, pH 7.6 with 0.1% sodium azide.
    应用
    应用 This Anti-Cytokeratin 8 Antibody, clone 4.1.18 is validated for use in WB, IC, IH, IH(P) for the detection of Cytokeratin 8.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    • Immunocytochemistry
    应用说明 Western blot Immunocytochemistry Immunohistochemistry: Frozen sections, acetone fixed (5-10 μg/mL)

    Paraffin sections, after trypsin treatment (5-20 μg/mL)

    Optimal-working dilutions must be determined by end user.
    生物信息
    免疫原品种 Cytoskeletal preparation of MCF-7 cells.
    克隆 4.1.18
    宿主 Mouse
    特异性 The antibody reacts with human cytokeratin 8. There is no cross reactivity with human cytokeratin No. 7, 17, 18, or 19. Anti-cytokeratin No. 8 decorates single epithelia in stomach, colon, and small intestine, gall bladder, liver (bile ducts and hepatocytes) as well as pancreatic ducts and mammary gland ducts.
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_002273.2
    基因符号
    • CARD2
    • KRT8
    • CYK8
    • CK-8
    • Cytokeratin-8
    • KO
    • K8
    • Keratin-8
    • K2C8
    • CK8
    UniProt编号
    • P05787
    UniProt汇总 FUNCTION: SwissProt: P05787 # Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
    SIZE: 483 amino acids; 53704 Da
    SUBUNIT: Heterotetramer of two type I and two type II keratins. keratin-8 associates with keratin-18. Associates with KRT20. Interacts with HCV core protein and PNN. When associated with KRT19, interacts with DMD. Interacts with TCHP.
    SUBCELLULAR LOCATION: Cytoplasm.
    TISSUE SPECIFICITY: Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
    PTM: Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.
    DISEASE:SwissProt: P05787 # Defects in KRT8 are a cause of cryptogenic cirrhosis [MIM:215600].
    SIMILARITY: SwissProt: P05787 ## Belongs to the intermediate filament family.
    MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain lyophilized material at +2-8°C for up to 12 months. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,MAB3414,Anti-Cytokeratin 8 Antibody, clone 4.1.18

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