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品种反应性 主要应用 宿主 格式 抗体类型 H ICC M Purified Monoclonal Antibody 描述 产品目录编号 MAB2630 描述 Anti-KRIT-1 Antibody, clone 15 Alternate Names - Krev interaction trapped 1
- Cerebral cavernous malformations 1 protein
背景信息 Cerebral cavernous malformation (CCM), a disease associated with defective endothelial junctions, results from autosomal dominant CCM1 mutations that cause a loss of KRIT-1 protein function. CCM1 has been identified as the KRIT-1 gene. The protein product, KRIT-1, also known as Krev interaction trapped protein 1, is a microtubule-associated protein involved in endothelial cell-cell and cell-extracellular matrix interactions. KRIT-1 binds to Rap1 that maintains the integrity of endothelial junctions. It is reported that KRIT-1 colocalizes and is physically associated with junctional proteins via its band 4.1/ezrin/radixin/moesin (FERM) domain, (Glading, 2007). 产品信息 格式 Purified 控制 - HeLa, A431, and HUVECs.
演示 Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 Anti-KRIT-1 Antibody, clone 15 detects level of KRIT-1 & has been published & validated for use in IC, IP & WB. 主要应用 - Immunocytochemistry
生物信息 免疫原品种 GST-tagged recombinant protein corresponding to human KRIT-1 at and around the FERM domain. 表位 FERM domain 克隆 15B2 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 The antibody recognizes KRIT-1. 同种型 IgG2bκ 品种反应性 Human Species Reactivity Note Demonstrated to react in human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_919436.1
Entrez基因汇总 This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]. 基因符号 - CCM1
- KRIT1
- CAM
纯化方法 Protein G purfied UniProt编号 - O00522
UniProt汇总 SUBUNIT STRUCTURE: Interacts with RAP1A.
SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein Probable.
TISSUE SPECIFICITY: Low levels in brain. Very weak expression found in heart and muscle.
INVOLVEMENT IN DISEASE: Defects in KRIT1 are the cause of cerebral cavernous malformations type 1 (CCM1) [MIM:116860]. Cerebral cavernous malformations (CCMs) are congenital vascular anomalies of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. CCMs have an incidence of 0.1%-0.5% in the general population and usually present clinically during the 3rd to 5th decade of life. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters.
SEQUENCE SIMILARITIES: Contains 4 ANK repeats.
Contains 1 FERM domain.产品使用声明 质量保证 Immunocytochemistry Analysis: 1:500 dilution of this antibody detected KRIT-1 in HeLa, A431, and HUVECs. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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