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品种反应性 主要应用 宿主 格式 抗体类型 H FC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MAB2626 描述 Anti-Endosialin Antibody, clone B1/35 Alternate Names - CD248 antigen
- CD248 molecule, endosialin
- CD164 sialomucin-like 1
- endosialin
- CD248 antigen, endosialin
- Tumor endothelial marker 1
背景信息 Endosialin is a glycoprotein on the cell surface of vascular endothelial cells in a broad range of human cancers. Endosialin is thought to be highly expressed at the points of active tissue remodeling and neovascularisation which may imply that endosialin is key in tumor growth, angiogenesis and metastasis. Endosialin has structural similarity to CD93, which involves a C-type lectin-like domain, EGF-like repeats and a glycosylated mucin-like domain. This similarity may also suggest that endosialin plays a role in innate immunity and inflammation. 产品信息 格式 Purified 控制 - AG1523 cell lysate
演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect Endosialin using this Anti-Endosialin Antibody, clone B1/35 validated for use in WB, IP, IF, FC. 主要应用 - Flow Cytometry
- Western Blotting
应用说明 Flow Cytometry Analysis: A previous lot was used by an independent laboratory in FC to detect Endosialin in rheumatoid fibroblasts (MacFadyen, J. et al. (2005). FEBS. 579(12):2569-2575).
Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP on AG1523 human fibroblasts (MacFadyen, J. et al. (2005). FEBS. 579(12):2569-2575).
Immunofluorescent Analysis: A previous lot was used by an independent laboratory in IF to detect Endosialin in human rheumatoid synovium, tonsil, salivary gland and normal breast tissues (MacFadyen, J. et al. (2005). FEBS. 579(12):2569-2575).生物信息 免疫原品种 Diploid human fibroblasts 克隆 B1/35 宿主 Mouse 同种型 IgG1κ 品种反应性 Human Species Reactivity Note Demonstrated to react with human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_065137
基因符号 - CD164L1
- CD248
- TEM1
纯化方法 Protein G Purified UniProt编号 - Q9HCU0
UniProt汇总 FUNCTION: May play a role in tumor angiogenesis.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein Probable.
TISSUE SPECIFICTY: Expressed in tumor endothelial cells but absent or barely detectable in normal endothelial cells. Expressed in metastatic lesions of the liver and during angiogenesis of corpus luteum formation and wound healing. Expressed in vascular endothelial cells of malignant tumors but not in normal blood vessels. Expressed in stromal fibroblasts.
PTM: O-glycosylated with sialylated oligosaccharides.
May be N-glycosylated.
SEQUENCE SIMILARITIES: Contains 1 C-type lectin domain.
Contains 1 EGF-like domain.
Contains 1 Sushi (CCP/SCR) domain.产品使用声明 质量保证 Evaluated by Western Blot in AG1523 cell lysate.
Western Blot Analysis: A 1:2,500 dilution of this antibody detected Endosialin in 10 µg of AG1523 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 200 µL
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