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merck millipore,默克密理博,MAB2613,Anti-UPAR-Associated Protein Antibody, clone 2.h.9:F12
产品名称：Anti-UPAR-Associated Protein Antibody, clone 2.h.9:F12
产品型号：MAB2613
Anti-UPAR-Associated Protein Antibody, clone 2.h.9:F12 is an antibody against UPAR-Associated Protein for use in WB, IH.
merck millipore,默克密理博,MAB2613,Anti-UPAR-Associated Protein Antibody, clone 2.h.9:F12
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MAB2613 描述 Anti-UPAR-Associated Protein Antibody, clone 2.h.9:F12 Alternate Names - C-type mannose receptor 2
- CD280
- Endocytic receptor 180
- Macrophage mannose receptor 2
- UPAR-associated protein
- Urokinase receptor-associated protein
背景信息 Urokinase plasminogen activator receptor-associated protein (uPARAP/Endo180/MRC2) is a member of the macrophage mannose receptor family of endocytic transmembrane glycoproteins. UPAR-Associated Protein is a membrane protein involved in matrix turnover during tissue remodeling, particularly the uptake and intracellular degradation of collagen, (Sulek, 2007). 产品信息 格式 Purified 控制 - U937 cell lysate
演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 Anti-UPAR-Associated Protein Antibody, clone 2.h.9:F12 is an antibody against UPAR-Associated Protein for use in WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
生物信息 免疫原品种 uPAR D3-tagged recombinant protein corresponding to human UPAR-Associated Protein. 表位 Unknown 克隆 2.h.9:F12 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 The antibody recognizes UPAR-Associated Protein. 同种型 IgG1κ 品种反应性 MouseHuman Species Reactivity Note Human and mouse. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_006030.2
Entrez基因汇总 MRC2 is a recycling endocytic receptor that functions in cell motility and remodeling of the extracellular matrix by promoting cell migration and uptake of collagens for intracellular degradation (Wienke et al., 2007 [PubMed 17974964]).[supplied by OMIM]. 基因符号 - UPARAP
- MRC2
- CD280
- CLEC13E
- ENDO180
纯化方法 Protein G purfied UniProt编号 - Q9UBG0
UniProt汇总 FUNCTION: May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix co-operating with the matrix metalloproteinases (MMPs).
SUBUNIT STRUCTURE: Interacts with C-terminal region of type I collagen/COL1A1 By similarity. Interacts directly with PLAUR/UPAR and PLAU/pro-UPA to form a tri-molecular complex. Interacts with collagen V.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney.
DOMAIN: C-type lectin domains 3 to 8 are not required for calcium-dependent binding of mannose, fucose and N-acetylglucosamine. C-type lectin domain 2 is responsible for sugar-binding in a calcium-dependent manner.
Fibronectin type-II domain mediates collagen-binding.
Ricin B-type lectin domain contacts with the second C-type lectin domain By similarity.
PTM: Phosphorylated.
N-glycosylated.
SEQUENCE SIMILARITIES: Contains 8 C-type lectin domains.
Contains 1 fibronectin type-II domain.
Contains 1 ricin B-type lectin domain.产品使用声明 质量保证 Evaluated by Western Blot in U937 cell lysate.
Western Blot Analysis: 0.2 µg/ml of this antibody detected UPAR-Associated Protein on 10 µg of U937 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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