merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB2605,Anti-ATG5 Antibody, clone 177.19

  • merck millipore,默克密理博,MAB2605,Anti-ATG5 Antibody, clone 177.19

    产品名称：Anti-ATG5 Antibody, clone 177.19
    产品型号：MAB2605
    This Anti-ATG5 Antibody, clone 177.19 is validated for use in WB, IP for the detection of ATG5.

    merck millipore,默克密理博,MAB2605,Anti-ATG5 Antibody, clone 177.19

  • 产品介绍
  • merck millipore,默克密理博,MAB2605,Anti-ATG5 Antibody, clone 177.19

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB2605
    Replaces MABC137
    描述 Anti-ATG5 Antibody, clone 177.19
    Alternate Names
    • apoptosis specific protein
    • APG5 autophagy 5-like
    • APG5 autophagy 5-like (S. cerevisiae)
    • APG5 (autophagy 5, S. cerevisiae)-like
    • ATG5 autophagy related 5 homolog (S. cerevisiae)
    • ATG5 autophagy related 5-like
    • Apoptosis-specific protein
    • Apoptosis-specific protein
    背景信息 ATG5 is required for autophagy. It conjugates to ATG12 and associates with isolation membrane to form autophagosomes. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. Conjugation to ATG12 is essential for autophagy, but is not required for association with isolation membrane. ATG5 also plays an important role in the apoptotic process. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity
    产品信息
    格式 Purified
    控制
    • Western Blot and Immunoprecipitation: HeLa cell lysate.
    演示 Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.
    应用
    应用 This Anti-ATG5 Antibody, clone 177.19 is validated for use in WB, IP for the detection of ATG5.
    主要应用
    • Western Blotting
    应用说明 Immunoprecipitation: HeLa cell lysate
    生物信息
    免疫原品种 Linear Peptide, aa: 8-318
    克隆 177.19
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 The antibody reacts with the 50 kDa ATG5 protein.
    同种型 IgG2bκ
    品种反应性 Human
    Species Reactivity Note Reacts with human. Other species have not been tested.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_004849.2
    基因符号
    • hAPG5
    • APG5
    • APG5-LIKE
    • APG5L
    • ASP
    纯化方法 Protein G purfied
    UniProt编号
    • Q9H1Y0
    UniProt汇总 FUNCTION: Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed By similarity.
    May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity.
    SUBCELLULAR LOCATION: Cytoplasm. Note= Colocalizes with nonmuscle actin.
    TISSUE SPECIFICTY: Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells.
    INDUCTION: By apoptotic stimuli.
    PTM: Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane.
    SEQUENCE SIMILARITIES: Belongs to the ATG5 family
    产品使用声明
    质量保证 Western Blot Analysis: 0.5 ug/mL of this antibody detected ATG5 on HeLa cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB2605,Anti-ATG5 Antibody, clone 177.19

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