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merck millipore,默克密理博,MAB2262,Anti-Excitatory amino acid transporter 2 Antibody, clone G6
产品名称：Anti-Excitatory amino acid transporter 2 Antibody, clone G6
产品型号：MAB2262
This Anti-Excitatory amino acid transporter 2 Antibody, clone G6 is validated for use in WB, IH, IC for the detection of Excitatory amino acid transporter 2.
merck millipore,默克密理博,MAB2262,Anti-Excitatory amino acid transporter 2 Antibody, clone G6
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M ICC, WB, IHC M Purified Monoclonal Antibody 描述 产品目录编号 MAB2262 描述 Anti-Excitatory amino acid transporter 2 Antibody, clone G6 Alternate Names - solute carrier family 1, member 2
- Glutamate/aspartate transporter II
- Sodium-dependent glutamate/aspartate transporter 2
- Solute carrier family 1 member 2
- excitatory amino acid transporter 2
- excitotoxic amino acid transporter 2
- glial high affinity glutamate transporter
- solute carrier family 1 (glial high affinity glutamate transporter), member 2
背景信息 The activity of the main glutamate transporter in the CNS, Excitatory amino acid transporter 2 (also known as GLT1), can be regulated by protein kinase C (PKC). It is known that activation of PKC by phorbol esters promotes the clathrin-dependent internalization of the transporter, followed by its lysosomal degradation. However, the molecular mechanisms that link PKC activation and the internalization of the excitatory amino acid transporter 2 are not fully understood. The internalization process may play a role in the ubiquitylation of lysine residues located in the C-terminal tail of the excitatory amino acid transporter 2. Exposure to PMA increases the ubiquitylation of the excitatory amino acid transporter 2 in transfected cells and in the rat brain, and this ubiquitylated excitatory amino acid transporter 2 accumulates in the intracellular compartment. The activation of PKC induces the ubiquitylation of these C-terminal lysine residues in the Excitatory amino acid transporter 2 and this modification mediates the interaction of the transporter with the endocytic machinery. 产品信息 格式 Purified 控制 - Mouse brain tissue lysate
演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 This Anti-Excitatory amino acid transporter 2 Antibody, clone G6 is validated for use in WB, IH, IC for the detection of Excitatory amino acid transporter 2. 主要应用 - Immunocytochemistry
- Western Blotting
- Immunohistochemistry
应用说明 Western Blot Analysis: 0.5 µg/ml from a previous lot detected Excitatory amino acid transporter 2 on 10 µg of human brain tissue lysate. 生物信息 免疫原品种 Linear peptide corresponding to the C-terminus of human Excitatory amino acid transporter 2. 表位 C-terminus 克隆 G6 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody recognizes the C-terminus of Excitatory amino acid transporter 2. 同种型 IgG1κ 品种反应性 RatHumanMouse Species Reactivity Note Demonstrated to react with human and mouse. Predicted to react with rat based on 100% immunogen peptide sequence homology. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_004162
Entrez基因汇总 This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. 基因符号 - GLT1
- SLC1A2
- EAAT2
- GLT-1
纯化方法 Protein G purfied UniProt编号 - P43004
UniProt汇总 FUNCTION: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.
SUBUNIT STRUCTURE: Homotrimer. Interacts with JUB By similarity.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
PTM: Glycosylated.
SEQUENCE SIMILARITIES: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. [View classification]产品使用声明 质量保证 Evaluated by Western Blot in mouse brain tissue lysate.
Western Blot Analysis: 0.5 µg/ml of this antibody detected Excitatory amino acid transporter 2 on 10 µg of mouse brain tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,129875,Amastatin, Streptomyces sp. - CAS 67655-94-1 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,03-113,RIPAb+ p54nrb/NonO - RIP Validated Antibody and Primer Set
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