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merck millipore,默克密理博,445800,Merbarone - CAS 97534-21-9 - Calbiochem
产品名称:Merbarone - CAS 97534-21-9 - Calbiochem
产品型号:445800
A cell-permeable anticancer drug that inhibits the catalytic activity of topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes.
merck millipore,默克密理博,445800,Merbarone - CAS 97534-21-9 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₁H₉N₃O₃S 97534-21-9 描述 概述 A cell-permeable anticancer drug that inhibits the catalytic activity of topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes (IC50 = 20 µM for purified mammalian topo II versus IC50 = ~ 200 µM for topo I). Also induces apoptosis in human leukemic CEM cells through a caspase-3-like protease-dependent mechanism. 产品目录编号 445800 品牌系列 Calbiochem®
同义词 5-(N-Phenylcarboxamido)-2-thiobarbituric Acid, NSC-336628 参考 参考 Khelifa, T., and Beck, W.T. 1999. Mol. Pharmacol. 55, 548.
Drake, F.H., et al. 1989. Cancer Res. 49, 2578.
Brewer, A.D., et al. 1985. Biochem. Pharmacol. 34, 2047.产品信息 CAS号 97534-21-9 具有ATP竞争性 N 形式 Faint pink solid Hill配方 C₁₁H₉N₃O₃S 化学配方 C₁₁H₉N₃O₃S Molar Mass 263.3 可逆 N 结构配方图像 生物信息 主靶 Catalytic activity of topoisomerase II 主靶IC50 20 µM for purified topoisomerase II (topo II) 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO GHS安全信息 RTECS UV7714625 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
包装信息 惰性气体下包装 Packaged under inert gas
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