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品种反应性 主要应用 宿主 格式 抗体类型 R, Av, H, M WB Rb Serum Polyclonal Antibody 描述 产品目录编号 06-133 Replaces MABT208; 04-353 品牌系列 Upstate
商名 - Upstate
描述 Anti-Fyn Antibody 产品信息 格式 Serum 演示 antiserum 应用 应用 This Anti-Fyn Antibody is validated for use in IP, WB for the detection of Fyn. 主要应用 - Western Blotting
生物信息 免疫原品种 Synthetic peptide corresponding to aa 35-51 (TPQHYPSFGVTSIPNYN) of human Fyn 宿主 Rabbit 特异性 Fyn 同种型 IgG 品种反应性 RatAvianHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_002037
Entrez基因汇总 This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. 基因符号 - p59-Fyn
- FYN
- SLK
- MGC45350
- SYN
纯化方法 Antiserum UniProt编号 - P06241
UniProt汇总 FUNCTION: SwissProt: P06241 # Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels, with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in comparison to isoform 1. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC.
COFACTOR: Manganese.
SIZE: 537 amino acids; 60762 Da
SUBUNIT: Associates through its SH3 domain, to the p85 subunit of phosphatidylinositol 3-kinase. Interacts with the FYN-binding protein (FYB). Interacts with phosphorylated TOM1L1. Interacts with CD79A upon activation of the B-cell antigen receptor which increases FYN activity (By similarity). Interacts with PAG1.
SUBCELLULAR LOCATION: Cell membrane. Note=Present and active in lipid rafts. Present in cell body and along the process of mature and developing oligodendroyctes.
TISSUE SPECIFICITY: Isoform 1 is highly expressed in the brain, isoform 2 is expressed in cells of hemopoietic lineages, especially T lymphocytes.
SIMILARITY: SwissProt: P06241 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.产品使用声明 质量保证 routinely evaluated by immunoblot on Jurkat cell lysate 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 250 µL
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