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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, ELISA, ICC M Purified Monoclonal Antibody 描述 产品目录编号 MAB2154 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-P-Selectin Antibody, clone P8G6 Alternate Names - PADGEM
- CD62P
- Granule Membrane Protein-140
- GMP-140
- Platelet Activation Dependent Granule-external Membrane Protein
产品信息 格式 Purified 演示 Purified in 0.02M PBS, 0.25M NaCl, pH 7.6 with 0.1% NaN3. Liquid 应用 应用 Detect P-Selectin using this Anti-P-Selectin Antibody, clone P8G6 validated for use in ELISA, IP, IC, IH. 主要应用 - Immunohistochemistry
- ELISA
- Immunocytochemistry
应用说明 Immunohistochemistry: for use on acetone or paraformaldehyde fixed tissue
Immunocytochemistry
Immunoprecipitation
ELISA
Inhibits P Selectin dependent interactions
Inhibits platelet binding to monocytes
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 IL-1beta activated HUVEC (human) 克隆 P8G6 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Human P Selectin 同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_003006.3
Entrez基因汇总 SELPLG is the high affinity counter-receptor for P-selectin on myeloid cells and stimulated T lymphocytes. As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin. The organization of the SELPG gene closely resembles that of CD43 and the human platelet glycoprotein GpIb-alpha both of which have an intron in the 5-prime-noncoding region, a long second exon containing the complete coding region, and TATA-less promoters. 基因符号 - PSGL1
- SELPLG
- CLA
- PSGL-1
- CD162
UniProt编号 - Q14242
UniProt汇总 FUNCTION: SwissProt: Q14242 # Binds to P-, E- and L-selectins. The calcium-dependent high affinity interaction with P-selectin mediates the tethering and rolling of neutrophils and T-lymphocytes on endothelial cells.
SIZE: 412 amino acids; 43201 Da
SUBUNIT: Homodimer; disulfide-linked.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Expressed on neutrophils, monocytes and most lymphocytes.
PTM: Displays complex, sialylated and fucosylated O-linked oligosaccharides, at least some of which appear to contain poly-N- acetyllactosamine with varying degrees of substitution. Also N- glycosylated. & Sulfated in the N-terminal region; sulfation is necessary for P-selectin binding.产品使用声明 销售限制 This product is not available for sale in the United States. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C in undiluted aliquots for up to 6 months. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,05-915,Anti-N-Cadherin Antibody, clone 13A9
下一件merck millipore产品：merck millipore,默克密理博,72157,BacMagic™-2 DNA Kit - Novagen
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