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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB, ICC M Purified Monoclonal Antibody 描述 产品目录编号 MAB2083 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-γ-Catenin Antibody, clone 11E4 Alternate Names - Plakoglobin
产品信息 格式 Purified 演示 Liquid at 1 mg/mL in 0.02 M phosphate buffer, pH 7.6, 0.25M NaCl, containing 0.1% sodium azide. 应用 应用 Detect γ-Catenin using this Anti-γ-Catenin Antibody, clone 11E4 validated for use in IP, WB, IC, IH. 主要应用 - Immunohistochemistry
- Western Blotting
- Immunocytochemistry
应用说明 Immunohistochemistry: Histochoice fixative is effective.
Immunocytochemistry: Effective for A431 and HT1080 cell lines.
Immunoblotting
Immunoprecipitation
Optimal working dilutions must be determined by end user.生物信息 克隆 11E4 宿主 Mouse 特异性 Produced by immunization with recombinant human G-catenin. 同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_021991.1
- NM_002230.1
Entrez基因汇总 This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. 基因符号 - Desmoplakin-3
- JUP
- PKGB
- CTNNG
- ARVD12
- PDGB
- gamma-catenin
- DP3
- DPIII
UniProt编号 - P14923
UniProt汇总 FUNCTION: SwissProt: P14923 # Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques.
SIZE: 744 amino acids; 81630 Da
SUBUNIT: Homodimer.
SUBCELLULAR LOCATION: Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Cytoplasmic in a soluble and membrane- associated form.
DISEASE: SwissProt: P14923 # Defects in JUP are the cause of Naxos disease [MIM:601214]. Naxos disease is an autosomal recessive disorder combining non-epidermolytic palmoplantar keratoderma with arrhythmogenic right ventricular cardiomyopathy and woolly hair.
SIMILARITY: SwissProt: P14923 ## Belongs to the beta-catenin family. & Contains 8 ARM repeats.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8°C in undiluted aliquots for up to12 months. 包装信息 数量 100 µg
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