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merck millipore,默克密理博,MAB2010,Anti-Cartilage Proteoglycan Antibody, fetal, clone HFPG-846
产品名称：Anti-Cartilage Proteoglycan Antibody, fetal, clone HFPG-846
产品型号：MAB2010
Anti-Cartilage Proteoglycan Antibody, fetal, clone HFPG-846 is an antibody against Cartilage Proteoglycan for use in ELISA, RIA, WB, IH.
merck millipore,默克密理博,MAB2010,Anti-Cartilage Proteoglycan Antibody, fetal, clone HFPG-846
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IHC, ELISA, WB M Ascites Monoclonal Antibody 描述 产品目录编号 MAB2010 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Cartilage Proteoglycan Antibody, fetal, clone HFPG-846 产品信息 格式 Ascites 演示 Ascites fluid. 应用 应用 Anti-Cartilage Proteoglycan Antibody, fetal, clone HFPG-846 is an antibody against Cartilage Proteoglycan for use in ELISA, RIA, WB, IH. 主要应用 - Immunohistochemistry
- ELISA
- Western Blotting
应用说明 Western Blot at 1:100-1:400.
ELISA at 1:1,000 - 1:4,000.
RIA at 1:200 - 1:4,000.
Immunohistochemistry (unfixed only) at 1:2 - 1:5.
Final working dilutions must be determined by end user.生物信息 免疫原品种 Native fetal human cartilage aggrecan. 表位 fetal 克隆 HFPG-846 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Recognizes a protein-related eptiope on the chondroitin sulfate-attachment region of native fetal human articular cartilage proteoglycan. Does not react with chondroitinase or hyaluronidase digested fetal human cartilage aggrecan. Cross-reactive with both fetal and adult aggrecans of other species. Fetal specificity is only demonstrated in the human system. 同种型 IgM 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_013227.2
- NM_001135.2
Entrez基因汇总 This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. 基因符号 - CSPGCP
- ACAN
- MSK16
- SEDK
- CSPCP
- AGCAN
- AGC1
- CSPG1
UniProt编号 - P16112
UniProt汇总 FUNCTION: SwissProt: P16112 # This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.
SIZE: 2415 amino acids; 250193 Da
SUBUNIT: Interacts with FBLN1 (By similarity).
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).
TISSUE SPECIFICITY: Restricted to cartilages.
DEVELOPMENTAL STAGE: Expression was detected in chondrocytes throughout the developing skeleton.
DOMAIN: SwissProt: P16112 Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3.
PTM: Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase.
DISEASE: SwissProt: P16112 # Defects in AGC1 are the cause of spondyloepiphyseal dysplasia type Kimberley (SEDK) [MIM:608361]. Spondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy.
SIMILARITY: Belongs to the aggrecan/versican proteoglycan family. & Contains 1 C-type lectin domain. & Contains 1 EGF-like domain. & Contains 1 Ig-like V-type (immunoglobulin-like) domain. & Contains 4 Link domains. & Contains 1 Sushi (CCP/SCR) domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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