merck millipore,默克密理愽
  • merck millipore,默克密理博,14-485M,IKKβ Protein, active, 250 µg

  • merck millipore,默克密理博,14-485M,IKKβ Protein, active, 250 µg

    产品名称：IKKβ Protein, active, 250 µg
    产品型号：14-485M
    Active, recombinant, full-length human IKKβ, containing N-terminal His6 tag, for use in Kinase Assays.

    merck millipore,默克密理博,14-485M,IKKβ Protein, active, 250 µg

  • 产品介绍
  • merck millipore,默克密理博,14-485M,IKKβ Protein, active, 250 µg

    描述
    产品目录编号 14-485M
    品牌系列 Upstate
    商名
    • Upstate
    描述 IKKβ Protein, active, 250 µg
    概述 Recombinant, full-length human IKKβ, containing N-terminal His6 tag
    应用
    应用 Active, recombinant, full-length human IKKβ, containing N-terminal His6 tag, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Expressed by baculovirus in Sf21 insect cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_001556.1
    Entrez基因汇总 NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]
    基因符号
    • IKK2
    • IKBKB
    • IKK-B
    • IKK-beta
    • FLJ40509
    • IKKB
    • IkBKB
    • NFKBIKB
    • MGC131801
    蛋白靶 IKKβ
    纯化方法 Ni2+/NTA-agarose
    靶子系列 Misc
    UniProt编号
    • O14920
    UniProt汇总 FUNCTION: SwissProt: O14920 # Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3 (By similarity).
    SIZE: 756 amino acids; 86564 Da
    SUBUNIT: Preferentially found as a heterodimer with IKK-alpha but also as a homodimer. Directly interacts with IKK-gamma/NEMO and TRPC4AP. The tripartite complex can also bind to MEKK1, MAP3K14/NIK, IKAP and IKB-alpha-p65-p50 complex. Phosphorylated IKB-alpha is further released from the complex. Found in a complex composed of NCOA2, NCOA3, IKKA, IKBKG and CREBBP. Interacts with SQSTM1 through PRKCZ or PRKCI. Forms an NGF-induced complex with IKBKB, PRKCI and TRAF6. May interact with MAVS/IPS1. Interacts with NALP2. Interacts with Yersinia yopJ.
    SUBCELLULAR LOCATION: Cytoplasm.
    TISSUE SPECIFICITY: Highly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis and peripheral blood.
    PTM: Upon cytokine stimulation, phosphorylated on Ser-177 and Ser- 181 by MEKK1 and/or MAP3K14/NIK; which enhances activity. Once activated, autophosphorylates on the C-terminal serine cluster; which decreases activity and prevents prolonged activation of the inflammatory response. & Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, which blocks the I-kappa-B signaling pathway.
    SIMILARITY: SwissProt: O14920 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. IkappaB kinase subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by phosphorylation of IKKtide
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 1 year at -70°C
    包装信息
    数量 250 µg
    包装 Also available in 10 μg size (cat#14-485) and in bulk (cat# 14-485-K).

    merck millipore,默克密理博,14-485M,IKKβ Protein, active, 250 µg

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下一件merck millipore产品：merck millipore,默克密理博,MSVMHTS0F,轴环垫圈结构


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