merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB1961Z,Anti-Integrin αVβ5 Antibody, clone P1F6, azide free

  • merck millipore,默克密理博,MAB1961Z,Anti-Integrin αVβ5 Antibody, clone P1F6, azide free

    产品名称：Anti-Integrin αVβ5 Antibody, clone P1F6, azide free
    产品型号：MAB1961Z
    Detect Integrin αVβ5 using this Anti-Integrin αVβ5 Antibody, clone P1F6, azide free validated for use in FC, IH.

    merck millipore,默克密理博,MAB1961Z,Anti-Integrin αVβ5 Antibody, clone P1F6, azide free

  • 产品介绍
  • merck millipore,默克密理博,MAB1961Z,Anti-Integrin αVβ5 Antibody, clone P1F6, azide free

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    H, ChIHC, FCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB1961Z
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Integrin αVβ5 Antibody, clone P1F6, azide free
    Alternate Names
    • MAB1961
    背景信息 The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha V chain. Alpha chain V undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
    产品信息
    格式 Purified
    控制
    • Epithelium, keratinocytes
    演示 Purified immunoglobulin in 0.01M phosphate buffer, pH 7.1, 0.15M NaCl containing no preservatives.
    应用
    应用 Detect Integrin αVβ5 using this Anti-Integrin αVβ5 Antibody, clone P1F6, azide free validated for use in FC, IH.
    主要应用
    • Immunohistochemistry
    • Flow Cytometry
    不建议的应用
    • Immunohistochemistry (Paraffin)
    应用说明 Inhibition of attachment of HT29 cells to vitronectin: >1:1,000

    Inhibition of attachment of carcinoma and melanoma cells to vitronectin

    Immunohistochemistry: for use on acetone or paraformaldehyde fixed tissue. (Staining of formalin-fixed tissues REQUIRES boiling tissue sections in 1mM EDTA, pH 8.0, for 10-20 min followed by cooling at RT for 20 min.)

    Immunocytochemistry: for use on human carcinomas, normal epithelium and keratinocytes 1:1500 (Acetone Fixed Only)

    Immunoprecipitation

    FACS

    EIA

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Human UCLA P3 cells (lung carcinoma)
    克隆 P1F6
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Reacts with the human integrin alphaVbeta5.
    同种型 IgG1
    品种反应性 HumanChicken
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_002210.2
    Entrez基因汇总 ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.
    基因符号
    • VNRA
    • ITGAV
    • DKFZp686A08142
    • MSK8
    • CD51
    纯化方法 Protein A purfied
    UniProt编号
    • P06756
    UniProt汇总 FUNCTION: SwissProt: P06756 # The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
    SIZE: 1048 amino acids; 116038 Da
    SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    SIMILARITY: SwissProt: P06756 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB1961Z,Anti-Integrin αVβ5 Antibody, clone P1F6, azide free

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