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品种反应性 主要应用 宿主 格式 抗体类型 H IHC M Ascites Monoclonal Antibody 描述 产品目录编号 MAB1954 Replaces 04-1131 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Integrin α4 Antibody, clone P4G9 Alternate Names - CD49d
产品信息 格式 Ascites 应用 应用 Detect Integrin α4 using this Anti-Integrin α4 Antibody, clone P4G9 validated for use in IH. 主要应用 - Immunohistochemistry
应用说明 Immunocytochemistry on Jurkat cells at 1:1,600.
Inhibits attachment of hematopoeitic cells and fibroblasts to fibronectin (note: sodium azide should be removed prior to attachment assay).
Optimal working dilutions must be determined by the end user.生物信息 克隆 P4G9 宿主 Mouse 特异性 Human integrin alpha4. The alpha4beta1 integrin receptor recognizes an RGD-independent alternative adhesion site in the CS-1 region of fibronectin. 同种型 IgG2bκ 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000885.4
Entrez基因汇总 The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. 基因符号 - CD49d
- ITGA4
- MGC90518
- VLA-4
- IA4
- CD49D
UniProt编号 - P13612
UniProt汇总 FUNCTION: SwissProt: P13612 # Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
SIZE: 1038 amino acids; 115333 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN, LPXN, and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
DOMAIN: SwissProt: P13612 The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion.
PTM: Phosphorylation on Ser-1027 inhibits PXN binding.
SIMILARITY: Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Store at -20 °C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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