merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB1789,Anti-Migration Inhibitory Factor Related Proteins 8 and 14 Antibody, clone AHN-17

  • merck millipore,默克密理博,MAB1789,Anti-Migration Inhibitory Factor Related Proteins 8 and 14 Antibody, clone AHN-17

    产品名称：Anti-Migration Inhibitory Factor Related Proteins 8 and 14 Antibody, clone AHN-17
    产品型号：MAB1789
    Detect Migration Inhibitory Factor Related Proteins 8 & 14 using this Anti-Migration Inhibitory Factor Related Proteins 8 & 14 Antibody, clone AHN-17 validated for use in WB & IC.

    merck millipore,默克密理博,MAB1789,Anti-Migration Inhibitory Factor Related Proteins 8 and 14 Antibody, clone AHN-17

  • 产品介绍
  • merck millipore,默克密理博,MAB1789,Anti-Migration Inhibitory Factor Related Proteins 8 and 14 Antibody, clone AHN-17

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HICC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB1789
    Replaces CBL269
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Migration Inhibitory Factor Related Proteins 8 and 14 Antibody, clone AHN-17
    Alternate Names
    • Calprotectin
    • MRP-8 & 9
    • Myeloid-Related Protein-8 & 9
    • Calgranulin A & B
    • S100 Calcium-binding Protein A8 & A9
    • Leukocyte L1 cplx Light & Heavy Chain
    背景信息 Migration inhibitory factor-related proteins (MRP) -8 and -14 belong to the S-100 family of calcium binding proteins associated with myeloid cell differentiation. They are highly expressed in resting neutrophils, keratinocytes (particularly in psoriasis), in infiltrating tissue macrophages and on epithelial cells in active inflammatory disease. The heterogeneity of macrophage subpopulations in chronic or acute inflammation is reflected by different expression of MRP8 and MRP14. Phagocytes expressing MRP8 and MRP14 belong to the early infiltrating cells, while MRP8 alone is found in chronic inflammatory tissues. The partially antagonistic functions of MRP8, MRP14 and of the Ca2+-dependent MRP8/14 heterocomplex makes them versatile mediators.
    产品信息
    格式 Purified
    演示 Purified immunoglobulin. Liquid in 0.02M Phosphate buffer, 0.25M NaCl with 0.1% sodium azide.
    应用
    应用 Detect Migration Inhibitory Factor Related Proteins 8 & 14 using this Anti-Migration Inhibitory Factor Related Proteins 8 & 14 Antibody, clone AHN-17 validated for use in WB & IC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry on ethanol fixed cells

    Immunoblotting on un-reduced gels

    Optimal dilutions must be determined by the end user.
    生物信息
    免疫原品种 Neutrophils
    克隆 AHN-17
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Migration Inhibitory Factor Releasing Proteins -8 and -14
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_002964.3
    Entrez基因汇总 The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis.
    基因符号
    • P8
    • S100A8
    • CFAG
    • Calgranulin-A
    • 60B8AG
    • MRP8
    • CGLA
    • L1Ag
    • MIF
    • MRP-8
    • MA387
    • CAGA
    • CP-10
    • NIF
    UniProt编号
    • P05109
    UniProt汇总 FUNCTION: SwissProt: P05109 # Expressed by macrophages in chronic inflammations. Also expressed in epithelial cells constitutively or induced during dermatoses. May interact with components of the intermediate filaments in monocytes and epithelial cells.
    SIZE: 93 amino acids; 10835 Da
    SUBUNIT: Homodimer.
    SIMILARITY: SwissProt: P05109 ## Belongs to the S-100 family. & Contains 2 EF-hand domains.
    MISCELLANEOUS: Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at 2-8°C in undiluted aliquots for up to 6 months from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB1789,Anti-Migration Inhibitory Factor Related Proteins 8 and 14 Antibody, clone AHN-17

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