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merck millipore,默克密理博,MAB1567,Anti-Myelin Associated Glycoprotein Antibody, clone 513
产品名称：Anti-Myelin Associated Glycoprotein Antibody, clone 513
产品型号：MAB1567
Detect Myelin Associated Glycoprotein using this Anti-Myelin Associated Glycoprotein Antibody, clone 513 validated for use in IC, IH & WB.
merck millipore,默克密理博,MAB1567,Anti-Myelin Associated Glycoprotein Antibody, clone 513
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Fg, B, Ch, H, M, R WB, ICC, IHC M Purified Monoclonal Antibody 描述 产品目录编号 MAB1567 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Myelin Associated Glycoprotein Antibody, clone 513 Alternate Names - MAG
背景信息 Myelin-associated glycoprotein (MAG),a member of the immunoglobulin superfamily, is a membrane glycoprotein of 100 kDa, and is thought to be involved in the process of myelination. Axonal regeneration in the adult central nervous system (CNS) is limited by two proteins in myelin, Nogo and MAG. MAG has been implicated in the inhibition of nerve regeneration in the CNS. 产品信息 格式 Purified 控制 - Rat hippocampus tissue, rat brain lysate, PC12 cells.
演示 Purified mouse monoclonal IgG1 in buffer containing 10 mM potassium phosphate buffer, 50 mM NaCl, pH 7.5. Contains no preservative. 应用 应用 Detect Myelin Associated Glycoprotein using this Anti-Myelin Associated Glycoprotein Antibody, clone 513 validated for use in IC, IH & WB. 主要应用 - Western Blotting
- Immunocytochemistry
- Immunohistochemistry
应用说明 Western Blot:
20 μg/mL of a previous lot was used on western blot under non-reducing conditions only.{See Ellezam, 2003}
Immunocytochemistry:
5-10 µg/mL of a previous lot was used, methanol fixation required.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 L2 epitope carrying glycoprotein extract of 1-2 day old chicken brain. 克隆 513 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Detects Myelin Associated Glycoprotein (MAG) in immunohistochemistry on frozen sections, immunocytochemistry and Western blot (under non-reducing conditions). MAB1567 is useful for myelinogenesis and multiple sclerosis studies. 同种型 IgG1 品种反应性 FrogBovineChickenHumanMouseRat Species Reactivity Note Human, rat, mouse, bovine, chicken, frog. 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_002361.2
Entrez基因汇总 The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. 基因符号 - GMA
- MAG
- SIGLEC4A
- SIGLEC-4A
- Siglec-4a
- S-MAG
纯化方法 Protein A purfied UniProt编号 - P20916
UniProt汇总 FUNCTION: SwissProt: P20916 # Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha2,3- linked sialic acid (By similarity).
SIZE: 626 amino acids; 69069 Da
SUBUNIT: Binds to RTN4R (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: SwissProt: P20916 ## Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. & Contains 4 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 Ig-like V-type (immunoglobulin-like) domain.产品使用声明 质量保证 Evaluated by immunohistochemistry on rat hippocampus.
Immunohistochemistry(paraffin):
Representative image from a previous lot.
Mouse anti-Myelin Associated Glycoprotein [MAG] (Catalog Number MAB1567) localization of MAG in rat hippocampus. Photo courtesy of Dr. Robert Sloviter, University of Arizona.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20ºC from date of receipt. 包装信息 数量 100 µg
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