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merck millipore,默克密理博,MAB1552,Anti-Myosin Antibody, ventricular heavy chain α/β, clone F26.2D11
产品名称：Anti-Myosin Antibody, ventricular heavy chain α/β, clone F26.2D11
产品型号：MAB1552
Anti-Myosin Antibody, ventricular heavy chain α/β, clone F26.2D11 is an antibody against Myosin for use in WB, IH.
merck millipore,默克密理博,MAB1552,Anti-Myosin Antibody, ventricular heavy chain α/β, clone F26.2D11
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB M Culture Supernatant Monoclonal Antibody 描述 产品目录编号 MAB1552 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Myosin Antibody, ventricular heavy chain α/β, clone F26.2D11 产品信息 格式 Culture Supernatant 演示 Liquid containing 0.1% sodium azide. 应用 应用 Anti-Myosin Antibody, ventricular heavy chain α/β, clone F26.2D11 is an antibody against Myosin for use in WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunochemistry: undiluted to 1:10
Western blotting: 1:10
Optimal dilutions must be determined by the end user.生物信息 免疫原品种 Human ventricular myosin 表位 ventricular heavy chain alpha/beta 克隆 F26.2D11 宿主 Mouse 特异性 Recognizes the LMM (light meromyosin) fragment of human ventricular myosin heavy chain (type alpha/beta) 同种型 IgG2a 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000257.2
Entrez基因汇总 MYH7 encodes the cardiac muscle beta (or slow) isoform of myosin. Changes in the relative abundance of MYH7 and MYH6 (the alpha, or fast, isoform of cardiac myosin heavy chain) correlate with the contractile velocity of cardiac muscle. Mutations in MYH7 are associated with familial hypertrophic cardiomyopathy. 基因符号 - MGC138376
- MYH7
- Myosin-7
- MYHCB
- MyHC-beta
- DKFZp451F047
- CMH1
- CMD1S
- MGC138378
- MPD1
UniProt编号 - P13533
- P12883
UniProt汇总 FUNCTION: SwissProt: P13533 # Muscle contraction.
SIZE: 1939 amino acids; 223690 Da
SUBUNIT: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
DOMAIN: SwissProt: P13533 The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
DISEASE: SwissProt: P13533 # Defects in MYH6 are a cause of familial hypertrophic cardiomyopathy (CMH) [MIM:192600]. Familial hypertrophic cardiomyopathy is a heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The prevalence of the disease in the general population is 0.2%. FHC is clinically heterogeneous, with inter- and intrafamilial variations ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. & Defects in MYH6 are the cause of atrial septal defect type 3 (ASD3) [MIM:160710]. ASD is one of the most common forms of congenital heart malformation. It is characterized by incomplete closure of the wall between the atria, resulting in blood flow from the left to the right atria.
SIMILARITY: Contains 1 IQ domain. & Contains 1 myosin head-like domain.
MISCELLANEOUS: Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2). & The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain frozen at -20°C for up to 12 months in undiluted aliquots. Avoid repeated freeze/thaw cycles. 包装信息 数量 1 mL
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