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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB M Culture Supernatant Monoclonal Antibody 描述 产品目录编号 MAB1548 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Myosin Antibody, heavy chain β 产品信息 格式 Culture Supernatant 演示 Supernatant in RPMI 1640, 10% FCS, 0.01% sodium azide. 应用 应用 Detect Myosin using this Anti-Myosin Antibody, heavy chain β validated for use in WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry: Neat (undiluted)
Western blot: 1:10
Optimal dilutions must be determined by the end user.生物信息 免疫原品种 Human ventricular myosin 表位 heavy chain beta 克隆 5B9 (aka 2C8) 宿主 Mouse 特异性 Recognizes the S1/S2 junction of human ventricular myosin heavy chain beta 同种型 IgG2a 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000257.2
Entrez基因汇总 MYH7 encodes the cardiac muscle beta (or slow) isoform of myosin. Changes in the relative abundance of MYH7 and MYH6 (the alpha, or fast, isoform of cardiac myosin heavy chain) correlate with the contractile velocity of cardiac muscle. Mutations in MYH7 are associated with familial hypertrophic cardiomyopathy. 基因符号 - MGC138376
- MYH7
- Myosin-7
- MYHCB
- MyHC-beta
- DKFZp451F047
- CMH1
- CMD1S
- MGC138378
- MPD1
UniProt编号 - P12883
UniProt汇总 FUNCTION: SwissProt: P12883 # Muscle contraction.
SIZE: 1935 amino acids; 223097 Da
SUBUNIT: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
DOMAIN: SwissProt: P12883 The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
DISEASE: SwissProt: P12883 # Defects in MYH7 are the cause of familial hypertrophic cardiomyopathy type 1 (CMH1) [MIM:192600]; also designated FHC or HCM. Hypertrophic cardiomyopathy is a heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The prevalence of the disease in the general population is 0.2%. FHC is clinically heterogeneous, with inter- and intrafamilial variations ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. & Defects in MYH7 are the cause of myosin storage myopathy [MIM:608358]. In this disorder, muscle biopsy shows type 1 fiber predominance and increased interstitial fat and connective tissue. Inclusion bodies consisting of the beta cardiac myosin heavy chain are present in the majority of type 1 fibers, but not in type 2 fibers. & Defects in MYH7 are a cause of dilated cardiomyopathy (CMD) [MIM:115200]. CMD is a disorder characterized by cardiac dilation and reduced systolic function. & Defects in MYH7 are the cause of Laing early-onset distal myopathy (MPD1) [MIM:160500]. MPD1 is an autosomal dominant disorder which differs from other distal myopathies in that onset is as early as 4 years of age. Selective weakness of the anterior tibial muscles is followed by weakness of the finger extensors and selected proximal muscle groups such as the hip abductors and rotators, the shoulder abductors and the sternocleidomastoids.
SIMILARITY: Contains 1 IQ domain. & Contains 1 myosin head-like domain.
MISCELLANEOUS: Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2). & The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 1 mL
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