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merck millipore,默克密理博,MAB11056,Anti-Poly(rC)-binding protein 2 Antibody, clone 6A3.2
产品名称：Anti-Poly(rC)-binding protein 2 Antibody, clone 6A3.2
产品型号：MAB11056
Anti-Poly(rC)-binding protein 2 Antibody, clone 6A3.2 is an antibody against Poly(rC)-binding protein 2 for use in WB & IC.
merck millipore,默克密理博,MAB11056,Anti-Poly(rC)-binding protein 2 Antibody, clone 6A3.2
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M ICC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MAB11056 描述 Anti-Poly(rC)-binding protein 2 Antibody, clone 6A3.2 Alternate Names - Alpha-CP2
- poly(rC) binding protein 2
- heterogenous nuclear ribonucleoprotein E2
- poly(rC)-binding protein 2
背景信息 Poly(rC)-binding protein 2 (also known as αCP2 and hnRNP E2) is a part of a highly conserved, widely expressed family of RNA-binding proteins. Every isoform belonging to the Poly(rC)-binding protein family is comprised of a characteristic repeat of three KH domains, a 70 amino acid hnRNP commonly found in a large variety of RNA binding proteins. The KH domain is necessary to the binding of RNA. Poly(rC)-binding protein 2 functions to bind mRNA through its KH domain in a manner that provides a high level of stability to the mRNA. Recent studies have identified 160 mRNAs that are consistently and specifically associated with Poly(rC)-binding protein 2 (Waggoner,2003). Expression of Poly(rC)-binding protein 2 has been observed in all tissues tested. 产品信息 格式 Purified 控制 - Hek293 cell lysate
演示 Purified mouse monoclonal IgG3κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Poly(rC)-binding protein 2 Antibody, clone 6A3.2 is an antibody against Poly(rC)-binding protein 2 for use in WB & IC. 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Immunocytochemistry Analysis: 1:500 dilution of this antibody has been shown to detect Poly(rC)-binding protein 2 in A431 cells. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human Poly(rC)-binding protein 2. 表位 aa 204-217 克隆 6A3.2 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody recognizes Poly(rC)-binding protein 2. 同种型 IgG3κ 品种反应性 RatHumanMouse Species Reactivity Note Demonstrated to react with human. Predicted to react with mouse and rat based on 100% sequence homology. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_001122383
Entrez基因汇总 The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. 基因符号 - alpha-CP2
- hnRNP-E2
- HNRPE2
纯化方法 Protein G purfied UniProt编号 - Q15366
UniProt汇总 FUNCTION: Major cellular poly(rC)-binding protein. Binds also poly(rU).
SUBUNIT STRUCTURE: Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.
TISSUE SPECIFICITY: Detected in all tissues examined.
PTM: Phosphorylated. The non-phosphorylated form(s) exhibited the strongest poly(rC)-binding activity.
SS=EQUENCE SIMLARITIES: Contains 3 KH domains.产品使用声明 质量保证 Evaluated by Western Blot in Hek293 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected Poly(rC)-binding protein 2 on 10 µg of Hek293 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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