merck millipore,默克密理愽
  • merck millipore,默克密理博,IHCR1003-6,Anti-Tyrosine Hydroxylase Antibody, prediluted

  • merck millipore,默克密理博,IHCR1003-6,Anti-Tyrosine Hydroxylase Antibody, prediluted

    产品名称：Anti-Tyrosine Hydroxylase Antibody, prediluted
    产品型号：IHCR1003-6
    Detect Tyrosine Hydroxylase using this Anti-Tyrosine Hydroxylase Antibody, prediluted validated for use in IH(P).

    merck millipore,默克密理博,IHCR1003-6,Anti-Tyrosine Hydroxylase Antibody, prediluted

  • 产品介绍
  • merck millipore,默克密理博,IHCR1003-6,Anti-Tyrosine Hydroxylase Antibody, prediluted

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Sqd, Dr, Ft, H, M, R, F, Fe, Fg, MlIH(P)RbPurifiedPolyclonal Antibody
    描述
    产品目录编号 IHCR1003-6
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Tyrosine Hydroxylase Antibody, prediluted
    背景信息 Tyrosine hydroxylase plays an important role in the physiology of adrenergic neurons. It is the first and rate-limiting enzyme involved in the biosynthesis of the catecholamines Dopamine and Norepinephrine from tyrosine. TH is, therefore, a useful marker for dopaminergic and noradrenergic neurons. The enzymatic activity of TH requires ferrous ions as cofactors and is believed to be regulated by phosphorylation. At least four isoforms of human TH have been identified which result from alternative splicing.
    产品信息
    格式 Purified
    演示 Liquid diluted in PBS, pH 7.2 with stabilizers, 0.2% Tween 20, and 0.1% ProClin 300 as preservative.
    应用
    应用 Detect Tyrosine Hydroxylase using this Anti-Tyrosine Hydroxylase Antibody, prediluted validated for use in IH(P).
    主要应用
    • Immunohistochemistry (Paraffin)
    应用说明 Antibody is prediluted and ready to use for Immunohistochemistry of formalin-fixed, paraffin-embedded tissues.

    Pretreatment: Heat Induced Epitope Retrieval (HIER). Recommend Citrate Buffer, pH 6.0 (Cat. No. 21545). No signal was detected without Epitope retrieval.

    Incubation: 30 minutes with IHC Select° Detection Kits.

    Tyrosine Hydroxylase has been prediluted for use as the primary antibody with Chemicon's IHC Select° Detection Kits and Protocols (Catalog Nos. DAB050, DET-HP1000, APR050, and DET-APR1000), but other supplier's IHC detection systems may be used.
    生物信息
    免疫原品种 Denatured tyrosine hydroxylase from rat pheochromocytoma (denatured by sodium dodecyl sulfate).
    宿主 Rabbit
    特异性 Tyrosine hydroxylase. By western blot, AB152 (the non-prediluted antibody) selective labels a single band at approximately 62 kDa (reduced) corresponding to Tyrosine Hydroxylase. It is expected that the antibody will react with most mammalian and many non-mammalian species.
    品种反应性 SquidDrosophilaFerretHumanMouseRatFishFelineFrogMollusk
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_199293.2
    • NM_000360.3
    • NM_199292.2
    Entrez基因汇总 Tyrosine hydroxylase is involved in the conversion of tyrosine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons.
    基因符号
    • EC 1.14.16.2
    • TH
    • TYH
    UniProt编号
    • P07101
    UniProt汇总 FUNCTION: SwissProt: P07101 # Plays an important role in the physiology of adrenergic neurons.
    COFACTOR: Fe(2+) ion.
    SIZE: 528 amino acids; 58524 Da
    TISSUE SPECIFICITY: Mainly expressed in the brain and adrenal glands.
    DISEASE: SwissProt: P07101 # Defects in TH are the cause of autosomal recessive Segawa syndrome [MIM:605407]; also known as DOPA-responsive dystonia. Typically, it begins in childhood or adolescence with progressive difficulty in walking and, in some cases, spasticity. Some cases present with parkinsonian symptoms in infancy and are referred to as autosomal recessive infantile parkinsonism.
    SIMILARITY: SwissProt: P07101 ## Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at 2-8°C. Refer to vial for expiration dating.
    包装信息
    数量 6 mL

    merck millipore,默克密理博,IHCR1003-6,Anti-Tyrosine Hydroxylase Antibody, prediluted

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