merck millipore,默克密理博,FCMAB426PE,Milli-Mark Anti-mouse CD44 (H-CAM)-PE Antibody, clone KM201

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
M	FC	R	Phycoerythrin	Monoclonal Antibody

描述
产品目录编号	FCMAB426PE
商名	Milli-Mark
描述	Milli-Mark® Anti-mouse CD44 (H-CAM)-PE Antibody, clone KM201
Alternate Names	hematopoietic cell E- and L-selectin ligand CD44 antigen (homing function and Indian blood group system) CDw44 antigen HCAM H-CAM HUTCH-1 Phagocytic glycoprotein I Extracellular matrix receptor III GP90 lymphocyte homing/adhesion receptor Heparan sulfate proteoglycan Hermes antigen Hyaluronate receptor Epican antigen gp90 homing receptor chondroitin sulfate proteoglycan 8
背景信息	CD44, also known as H-CAM is a distinct adhesion molecule that, with its 13 known isoforms, comprises a family of transmembrane glycoproteins involved in a wide variety of significant biological processes. Members belonging to this family are involved in apoptosis, migration, metastasis, tumor progression, lymphocyte homing, and the attachment of hematopoietic cells to stromal cells. CD44 is the primary cell surface receptor for hyaluronic acid (HA), and is also a notable target for WNT signaling within the intestinal mucosa. Recent studies have used CD44 marker as a means to isolate different cancer stem cells (CSC) such as; colorectal CSC, pancreatic CSC, and prostate CSC.

产品信息
格式	Phycoerythrin
控制	mouse splenocytes
演示	Purified rat monoclonal IgG1 conjugated to PE in PBS with 0.1% sodium azide and 15 mg/mL BSA.

应用
应用	This Milli-Mark Anti-mouse CD44 (H-CAM)-PE Antibody, clone KM201 is validated for use in FC for the detection of mouse CD44 (H-CAM).
主要应用	Flow Cytometry

生物信息
免疫原品种	Mouse bone marrow-derived stromal cells
表位	Near the hyaluronate binding domain
克隆	KM201
宿主	Rat
特异性	The antibody recognizes CD44 near the hyaluronate binding domain.
同种型	IgG1κ
品种反应性	Mouse
Species Reactivity Note	Tested and passed on Mouse.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_001034240
基因符号	Pgp1 CD44 CD44R CDW44 CDw44 CSPG8 ECMR-III Epican HCELL HUTCH-I IN LHR MC56 MDU2 MDU3 MIC4 MUTCH-I PGP-1 PGP-I
纯化方法	Protein G Purified
UniProt编号	P15379
UniProt汇总	FUNCTION: Main cell surface receptor for hyaluronate. Adhesion to mucosal high endothelial venule and to types I and VI collagen. Probably involved in matrix adhesion, lymphocyte activation and lymph node homing. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. PTM: N-glycosylated By similarity. O-glycosylated; contains chondroitin sulfate glycans which can be more or less sulfated (By similarity). Phosphorylated; activation of PKC results in the dephosphorylation of Ser-742 (constitutive phosphorylation site), and the phosphorylation of Ser-708 (By similarity). POLYMORPHISM: Two allelic forms of this glycoprotein, PGP-1.1 and PGP-1.2, have been reported. The expressed product is PGP-1.1 (Ly-24.1). SEQUENCE SIMILARITIES: Contains 1 Link domain.

产品使用声明
质量保证	Evaluated by flow cytometry using mouse splenocytes
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.

包装信息
数量	100 tests

merck millipore,默克密理博,FCMAB426PE,Milli-Mark Anti-mouse CD44 (H-CAM)-PE Antibody, clone KM201

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