merck millipore,默克密理愽
  • merck millipore,默克密理博,07-739,Anti-phospho-ZAP-70 (Tyr319) Antibody

  • merck millipore,默克密理博,07-739,Anti-phospho-ZAP-70 (Tyr319) Antibody

    产品名称：Anti-phospho-ZAP-70 (Tyr319) Antibody
    产品型号：07-739
    Anti-phospho-ZAP-70 (Tyr319) Antibody detects level of phospho-ZAP-70 (Tyr319) & has been published & validated for use in WB.

    merck millipore,默克密理博,07-739,Anti-phospho-ZAP-70 (Tyr319) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-739,Anti-phospho-ZAP-70 (Tyr319) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-739
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-ZAP-70 (Tyr319) Antibody
    产品信息
    格式 Affinity Purified
    应用
    应用 Anti-phospho-ZAP-70 (Tyr319) Antibody detects level of phospho-ZAP-70 (Tyr319) & has been published & validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated, synthetic peptide ...SP[pY]SD... in which pY corresponds to phosphorylated tyrosine at residue 319 of human ZAP-70
    宿主 Rabbit
    特异性 phospho-ZAP-70 (Tyr319); an additional protein was also detected at ~150 kDa
    同种型 IgG
    品种反应性 Human
    Species Reactivity Note due to sequence conservation, broad species cross reactivity is expected
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_207519.1
    • NM_001079.3
    Entrez基因汇总 This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
    基因符号
    • SRK
    • ZAP70
    • ZAP-70
    • STD
    • TZK
    修改
    • Phosphorylation
    纯化方法 Immunoaffinity purified
    UniProt编号
    • P43403
    UniProt汇总 FUNCTION: SwissProt: P43403 # Associates with the T-cell antigen receptor zeta chain (CD3Z). Plays a role in lymphocyte activation.
    SIZE: 619 amino acids; 69872 Da
    SUBUNIT: Interacts with SLA2 when it is phosphorylated. Interacts with CD3Z and with phosphorylated NFAM1. Interacts with CBLB (By similarity). Interacts with CBL and SLA when it is phosphorylated. The association with SLA (or SLA2) and CBL probably leads to its destruction. Interacts with SHB. Interacts with DEF6 (By similarity).
    TISSUE SPECIFICITY: Expressed in T- and natural killer cells.
    DOMAIN: SwissProt: P43403 The SH2 domain binds to the phosphorylated tyrosine-based activation motif (TAM) of CD3Z.
    PTM: Phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation. Tyr-319 phosphorylation is essential for full activity.
    DISEASE:SwissProt: P43403 # Defects in ZAP70 are the cause of selective T-cell defect (STD) [MIM:176947]. STD is an autosomal recessive form of severe combined immunodeficiency characterized by a selective absence of CD8-type T-cells.
    SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily. & Contains 1 protein kinase domain. & Contains 2 SH2 domains.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot using RIPA lysates from Jurkat cells treated with 10mM hydrogen peroxide for 3 minutes
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 1 year at -20°C from date of shipment
    包装信息
    数量 100 µL

    merck millipore,默克密理博,07-739,Anti-phospho-ZAP-70 (Tyr319) Antibody

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