merck millipore,默克密理愽
  • merck millipore,默克密理博,FCMAB418PE,Milli-Mark™ Anti-CAR-PE Antibody, clone RmcB

  • merck millipore,默克密理博,FCMAB418PE,Milli-Mark™ Anti-CAR-PE Antibody, clone RmcB

    产品名称：Milli-Mark™ Anti-CAR-PE Antibody, clone RmcB
    产品型号：FCMAB418PE
    Detect CAR using this Milli-Mark Anti-CAR-PE Antibody, clone RmcB validated for use in FC.

    merck millipore,默克密理博,FCMAB418PE,Milli-Mark™ Anti-CAR-PE Antibody, clone RmcB

  • 产品介绍
  • merck millipore,默克密理博,FCMAB418PE,Milli-Mark™ Anti-CAR-PE Antibody, clone RmcB

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFCMPhycoerythrinMonoclonal Antibody
    描述
    产品目录编号 FCMAB418PE
    商名
    • Milli-Mark
    描述 Milli-Mark™ Anti-CAR-PE Antibody, clone RmcB
    Alternate Names
    • coxsackie virus and adenovirus receptor
    • 46 kD coxsackievirus and adenovirus receptor (CAR) protein
    • CVB3 binding protein
    • CVB3-binding protein
    • Coxsackievirus B-adenovirus receptor
    • coxsackie virus B receptor
    背景信息 The coxsackievirus and adenovirus receptor (CAR) mediates cell attachment and infection by coxsackie B viruses and by a number of adenoviruses. CAR also mediates homotypic intercellular interactions. In polarized epithelial cells, CAR is closely associated with the tight junction, where it contributes to the barrier to paracellular flow of solutes and macromolecules. CAR's biological roles are not well defined, but emerging evidence suggests that it may function during embryonic development and in regulating cell proliferation.
    产品信息
    格式 Phycoerythrin
    控制
    • HT-29 cells
    演示 Purified mouse monoclonal IgG1 conjugated to PE in PBS with 0.1% sodium azide and 15 mg/mL BSA.
    应用
    应用 Detect CAR using this Milli-Mark Anti-CAR-PE Antibody, clone RmcB validated for use in FC.
    主要应用
    • Flow Cytometry
    生物信息
    免疫原品种 Native human coxsackie virus-adenovirus receptor protein
    克隆 RmcB
    宿主 Mouse
    特异性 Antibody recognizes CAR.
    同种型 IgG1
    品种反应性 Human
    Species Reactivity Note Tested and passed on Human. Unconjugated version Cat. No. 05-644 is known to react with Mouse and Rat.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001329
    基因符号
    • HCAR
    • CXADR
    • CAR
    • hCAR
    • HCVADR
    纯化方法 Protein G Purified
    UniProt编号
    • P78310
    UniProt汇总 FUNCTION: SwissProt: P78310 # Receptor for group B coxsackieviruses and subgroup C of adenoviruses (AD2 and AD5), susceptibility to infection is correlated to its level of expression and availability at the plasma membrane of cells.

    SIZE: 365 amino acids; 40030 Da

    SUBUNIT: Monomer. Probably homodimer formed by 2 molecules on adjacent cells. Interacts with LNX, MPDZ, BAIAP1, DLG4, PRKCABP, TJP1 and CTNNB1. Secreted isoform 3, isoform 4 and isoform 5 can interact with the extracellular domain of the receptor. Binds adenovirus 12 fiber protein. Isoform 5 but not isoform 3 binds to coxsackievirus.

    SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. Note=In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions. In airway epithelial cells localized to basolateral membrane but not to apical surface. & Isoform 2: Cell membrane; Single-pass type I membrane protein. Note=In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions. In airway epithelial cells localized to basolateral membrane but not to apical surface. & Isoform 3: Secreted. & Isoform 4: Secreted. & Isoform 5: Secreted.

    TISSUE SPECIFICITY: Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitoulsy expressed while isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy.

    DOMAIN: SwissProt: P78310 The Ig-like C2-type 1 domain probably mediates homodimerization and interaction with JAML. & The PDZ-binding motif mediates interaction with MPDZ and BAIAP1.

    PTM: N-glycosylated (By similarity). & Palmitoylated on Cys-259 and/or Cys-260; required for proper localization to the plasma membrane.

    SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    产品使用声明
    质量保证 Evaluated by flow cytometry using HT-29 cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
    包装信息
    数量 100 tests

    merck millipore,默克密理博,FCMAB418PE,Milli-Mark™ Anti-CAR-PE Antibody, clone RmcB

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