- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,FCMAB375A4,Milli-Mark™ Anti-Integrin β1-Alexa Fluor 488 Antibody, clone P5D2
产品名称：Milli-Mark™ Anti-Integrin β1-Alexa Fluor 488 Antibody, clone P5D2
产品型号：FCMAB375A4
Milli-Mark Anti-Integrin β1-Alexa Fluor 488 Antibody, clone P5D2 detects level of Integrin β1 & has been published & validated for use in FC.
merck millipore,默克密理博,FCMAB375A4,Milli-Mark™ Anti-Integrin β1-Alexa Fluor 488 Antibody, clone P5D2
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H FC M AlexaFluor®488 Monoclonal Antibody 描述 产品目录编号 FCMAB375A4 商名 - Milli-Mark
描述 Milli-Mark™ Anti-Integrin β1-Alexa Fluor® 488 Antibody, clone P5D2 Alternate Names - CD29
背景信息 Integrin beta 1, also known as CD29, is a 130 kDa transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits (including alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6) to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. Interactions between integrins and the extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression. 产品信息 格式 AlexaFluor®488 控制 - A431 cells
演示 Purified mouse monoclonal IgG1 conjugated toAlexa Fluor® 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA. 应用 应用 Milli-Mark Anti-Integrin β1-Alexa Fluor 488 Antibody, clone P5D2 detects level of Integrin β1 & has been published & validated for use in FC. 主要应用 - Flow Cytometry
生物信息 免疫原品种 Human keratinocytes derived from skin.
克隆 P5D2 宿主 Mouse 特异性 Reacts with Human Integrin Beta 1. 同种型 IgG1 品种反应性 Human Species Reactivity Note Tested and passed on Human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_002202
基因符号 - MSK12
- ITGB1
- GPIIA
- OTTHUMP00000063731
- OTTHUMP00000046253
- OTTHUMP00000063733
- VLAB
- OTTHUMP00000063732
- MDF2
- FNRB
- CD29
纯化方法 Protein A Purified UniProt编号 - P05556
UniProt汇总 FUNCTION: SwissProt: P05556 # Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta- 1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha- 1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha- 3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha- 10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
SIZE: 798 amino acids; 88465 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha- 5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. Interacts with FLNA. Binds LGALS3BP and ITGB1BP3, when associated with alpha-7, but not with alpha-5 (By similarity). Interacts with FLNB and RANBP9. Isoform Beta-1D interacts with ACE2. Isoform Beta-1A interacts with the C-terminal region of FLNC. Interacts with HIV-1 Tat.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Isoform beta-1B does not localize to focal adhesions. Highly enriched in stage I melanosomes.
TISSUE SPECIFICITY: Isoform beta-1A is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. Isoform beta-1B is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbelical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform beta-1C and isoform beta-1C-2 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform beta-C-2, rather than isoform beta-1C, is selectively expressed in primary T-cells. Isoform beta-1C is expressed in nonproliferating and differentiated prostate gland epithelial cells. Isoform beta-1D is expressed specifically in striated muscle (skeletal and cardiac muscle).产品使用声明 质量保证 Evalluated by flow cytometry using A431 cells. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt. 包装信息 数量 100 tests
上一件merck millipore产品：merck millipore,默克密理博,14-1053,Human recombinant histone H2AZ-H2B dimers
下一件merck millipore产品：merck millipore,默克密理博,AG243,Midkine, recombinant human
相关产品
merck millipore,默克密理博,539128,Protease Inhibitor Set - Calbiochem
merck millipore,默克密理博,345757,Anti-Ganglioside GM₁ Rabbit pAb
merck millipore,默克密理博,SF-1088,GNAS; Human, Cyanine 5, RNA Detection Probe,SmartFlare
merck millipore,默克密理博,391336,Bicine, ULTROL Grade - CAS 150-25-4 - Calbiochem
merck millipore,默克密理博,14-1053,Human recombinant histone H2AZ-H2B dimers
merck millipore,默克密理博,AG243,Midkine, recombinant human
merck millipore,默克密理博,06-1119,Anti-TLR2 Antibody
merck millipore,默克密理博,3700-OP,OmniPur DNA Extraction Buffer - Calbiochem
merck millipore,默克密理博,AP107-KC,Rabbit Anti Goat Fc (KC) - MG