merck millipore,默克密理博,FCMAB288A6,Milli-Mark™ Anti-Ubiquitin Antibody, Lys63-Specific-Alexa Fluor647, clone Apu3

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
H	FC	Rb	AlexaFluor®647	Polyclonal Antibody

描述
产品目录编号	FCMAB288A6
商名	Milli-Mark
描述	Milli-Mark™ Anti-Ubiquitin Antibody, Lys63-Specific-Alexa Fluor®647, clone Apu3
背景信息	Polyubiquitin chains linked through the Lys48 residue of ubiquitin are most commonly associated with proteins targeted for proteosomal degradation. In contrast, polyubiquitin chains linked through the Lys63 residue of ubiquitin (Ub) are associated with nonproteolytic functions such as signal transduction. Lys63-linked polyUb chains connect components of NFκB signaling in a highly regulated manner, and genetic evidence indicates the involvement of Lys63-linked Ub chains in stress response and DNA repair. Research in yeast has suggested Lys63-linked Ub chains stimulate endocytosis.

产品信息
格式	AlexaFluor®647
控制	HeLa cells
演示	Purified recombinant rabbit monoclonal IgG1 conjugated to Alexa Fluor 647 in PBS with 0.1% sodium azide and 15 mg/mL BSA.

应用
应用	This Milli-Mark Anti-Ubiquitin Antibody, Lys63-Specific-Alexa Fluor®647, clone Apu3 is validated for use in FC for the detection of Ubiquitin.
主要应用	Flow Cytometry

生物信息
免疫原品种	Immunogen used was di-ubiquitin linked at Lys63.
表位	Lys63 ubiquitination site
克隆	Apu3
宿主	Rabbit
特异性	Recognizes ubiquitin linked at Lys63. Does not recognize ubiquitin linked at Lys48 or free ubiquitin.
同种型	IgG
品种反应性	Human
Species Reactivity Note	Tested and passed on Human.
抗体类型	Polyclonal Antibody
纯化方法	Protein A Purified
UniProt编号	P0CG48
UniProt汇总	FUNCTION: Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous functions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair. Ref.21 SUBCELLULAR LOCATION: Cytoplasm. Nucleus. PTM: Several types of polymeric chains can be formed, depending on the lysine used for the assembly. MISCELLANEOUS: Ubiquitin is synthesized as a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains. In some species there is a final amino-acid after the last repeat, here in human a Val. Some ubiquitin genes contain a single copy of ubiquitin fused to a ribosomal protein (either L40 or S27a). SIMILARITY: Belongs to the ubiquitin family.

产品使用声明
质量保证	Evaluated by flow cytometry using HeLa cells
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain refrigerated at 2-8°C protected from light for up to 6 months from date of receipt.

包装信息
数量	100 tests

merck millipore,默克密理博,FCMAB288A6,Milli-Mark™ Anti-Ubiquitin Antibody, Lys63-Specific-Alexa Fluor647, clone Apu3

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